			SEQUENCE LISTING

<110> CODEXIS, INC.
 
<120> ENGINEERED GALACTOSE OXIDASE VARIANT ENZYMES
 
<130> CX2-176WO2
 
<140> 
<141> 2019-07-02

<150> 62/695,570
<151> 2018-07-06

<150> 62/822,286
<151> 2019-03-22
  
<160> 2860
 
<210> 1
<211> 1965
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac aaaagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgatttcga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc catttgaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaagt gataa                 1965

 
<210> 2
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Lys Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Phe Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Phe Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys 
                645                 650                         
 
<210> 3
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 3
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 4
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 4
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 5
<211> 1965
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 5
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cacaggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaagt gataa                 1965

 
<210> 6
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 6
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Gln Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys 
                645                 650                         

 
<210> 7
<211> 1965
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 7
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaagt gataa                 1965

 
<210> 8
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 8
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys 
                645                 650                         

 
<210> 9
<211> 1965
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 9
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaagt gataa                 1965

 
<210> 10
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 10
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys 
                645                 650                         

 
<210> 11
<211> 1965
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 11
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaagt gataa                 1965

 
<210> 12
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 12
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys 
                645                 650                         

 
<210> 13
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 13
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaaagc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 14
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 14
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Lys Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 15
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 15
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 16
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 16
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 17
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 17
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacat cgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 18
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 18
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Ser Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 19
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 19
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgagaa gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 20
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 20
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Lys Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 21
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 21
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgtg 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 22
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 22
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Val Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 23
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 23
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtactacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 24
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 24
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Thr Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 25
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 25
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat gctaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 26
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 26
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Ala Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 27
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 27
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcag tgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 28
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 28
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Ser Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 29
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 29
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctacgggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 30
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 30
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Thr Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 31
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 31
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggagttc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 32
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 32
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Val Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 33
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 33
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtctt 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 34
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 34
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Leu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 35
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 35
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcct tgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 36
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 36
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Leu Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 37
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 37
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtagctga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 38
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 38
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Ala Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 39
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 39
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctggtggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 40
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 40
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Gly Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 41
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 41
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcgcggga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 42
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 42
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Arg Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 43
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 43
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactcct 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 44
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 44
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Pro Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 45
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 45
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcga tgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 46
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 46
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Asp Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 47
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 47
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg gggataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 48
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 48
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Gly Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 49
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 49
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 50
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 50
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 51
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 51
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgtgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 52
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 52
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Val Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 53
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 53
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtattgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 54
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 54
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Ile 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 55
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 55
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tactaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 56
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 56
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Thr Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 57
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 57
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tggcgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 58
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 58
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Ala Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 59
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 59
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggca atgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 60
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 60
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Asn Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 61
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 61
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcga ggattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 62
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 62
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Glu Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 63
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 63
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcacgtgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 64
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 64
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Thr Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 65
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 65
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatgg ggcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 66
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 66
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Gly Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 67
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 67
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac agacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 68
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 68
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Gln Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 69
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 69
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtatggga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 70
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 70
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Trp Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 71
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 71
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgtctcact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 72
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 72
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Ser His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 73
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 73
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtctgtg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 74
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 74
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Cys Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 75
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 75
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccaagtg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 76
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 76
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 77
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 77
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccatgtg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 78
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 78
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Cys Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 79
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 79
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgagaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 80
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 80
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Glu Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 81
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 81
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatacgg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 82
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 82
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Thr Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 83
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 83
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
tctaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 84
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 84
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Ser Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 85
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 85
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctaggggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 86
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 86
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Arg Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 87
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 87
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcagcaggcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 88
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 88
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Gln Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 89
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 89
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caggggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 90
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 90
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 91
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 91
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccctt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 92
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 92
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Leu Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 93
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 93
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactcgg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 94
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 94
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Arg Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 95
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 95
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg tgctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 96
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 96
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ala Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 97
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 97
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 98
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 98
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 99
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 99
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gcgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 100
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 100
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Ala Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 101
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 101
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gttaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 102
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 102
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Val Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 103
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 103
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtccg 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 104
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 104
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Pro Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 105
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 105
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgacct cggataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 106
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 106
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ser Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 107
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 107
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtatcgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 108
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 108
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Ser Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 109
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 109
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaaggc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 110
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 110
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Arg Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 111
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 111
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa actactttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 112
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 112
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Thr Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 113
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 113
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg tacgcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 114
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 114
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Thr Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 115
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 115
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtggt 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 116
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 116
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Gly Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 117
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 117
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtacttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 118
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 118
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Leu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 119
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 119
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgttcg 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 120
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 120
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ser Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 121
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 121
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtatggatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 122
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 122
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Met 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 123
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 123
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt ctgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 124
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 124
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Leu Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 125
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 125
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 126
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 126
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 127
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 127
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggca aggtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcgcca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 128
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 128
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Lys Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 129
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 129
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgggc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 130
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 130
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Gly Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 131
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 131
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggct ctgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 132
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 132
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Ser Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 133
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 133
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt tgtccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 134
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 134
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Cys Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 135
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 135
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg tggtcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 136
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 136
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Gly Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 137
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 137
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacct tttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 138
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 138
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Leu Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 139
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 139
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcat ggattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 140
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 140
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Met Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 141
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 141
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacag ttacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 142
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 142
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Val Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 143
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 143
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggttgtacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 144
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 144
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Cys Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 145
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 145
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg tgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 146
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 146
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Val Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 147
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 147
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcagtatgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 148
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 148
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Tyr Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 149
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 149
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
cctaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 150
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 150
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Pro Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 151
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 151
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcgggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 152
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 152
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Arg Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 153
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 153
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgagag ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 154
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 154
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 155
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 155
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtaatttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 156
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 156
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Asn Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 157
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 157
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtggtttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 158
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 158
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gly Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 159
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 159
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 160
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 160
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 161
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 161
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 162
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 162
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Met Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 163
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 163
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa actaggttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 164
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 164
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Arg Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 165
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 165
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 166
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 166
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 167
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 167
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgagttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 168
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 168
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 169
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 169
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 170
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 170
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 171
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 171
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gttcgttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 172
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 172
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Ser Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 173
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 173
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttaata aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 174
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 174
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Asn Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 175
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 175
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattattt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 176
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 176
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Phe Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 177
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 177
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa actgtgttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 178
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 178
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Val Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 179
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 179
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttctta aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 180
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 180
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Leu Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 181
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 181
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caatggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 182
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 182
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Met Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 183
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 183
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactcct 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 184
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 184
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Pro Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 185
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 185
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcaa ggattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 186
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 186
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Lys Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 187
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 187
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa actatgttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 188
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 188
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Met Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 189
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 189
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 190
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 190
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 191
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 191
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttcata aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 192
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 192
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val His Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 193
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 193
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcacttgt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 194
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 194
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Cys Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 195
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 195
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttatga aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 196
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 196
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Met Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 197
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 197
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccatctg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 198
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 198
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 199
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 199
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa actactttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 200
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 200
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Thr Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 201
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 201
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
tataaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 202
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 202
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Tyr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 203
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 203
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcacttcg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 204
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 204
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 205
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 205
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caggggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 206
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 206
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 207
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 207
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattgttc tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccccg 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 208
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 208
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Val Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 209
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 209
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctagtggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 210
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 210
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Ser Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 211
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 211
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgcag gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 212
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 212
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ala Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 213
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 213
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgagtc ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttaccc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 214
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 214
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 215
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 215
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg aggtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 216
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 216
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Glu Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 217
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 217
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gcgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 218
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 218
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Ala Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 219
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 219
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 220
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 220
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 221
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 221
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gttaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 222
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 222
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Val Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 223
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 223
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtctcgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 224
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 224
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 225
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 225
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtatcgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 226
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 226
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Ser Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 227
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 227
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gctccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 228
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 228
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Ala Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 229
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 229
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgagac ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 230
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 230
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Thr Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 231
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 231
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcgtgtgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 232
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 232
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Val Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 233
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 233
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctaatggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 234
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 234
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Asn Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 235
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 235
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcc aggtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 236
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 236
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gln Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 237
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 237
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggct ctgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 238
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 238
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Ser Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 239
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 239
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactatg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 240
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 240
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Met Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 241
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 241
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcgaggga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 242
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 242
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Arg Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 243
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 243
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctgcgggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 244
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 244
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Ala Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 245
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 245
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
cagaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 246
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 246
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gln Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 247
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 247
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
ggtaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 248
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 248
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 249
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 249
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggggga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 250
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 250
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Gly Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 251
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 251
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcg 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 252
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 252
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 253
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 253
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgctc ggattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 254
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 254
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Ser Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 255
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 255
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gacttcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 256
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 256
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Thr Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 257
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 257
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgagaa gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 258
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 258
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Lys Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 259
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 259
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 260
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 260
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 261
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 261
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcga tgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 262
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 262
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Asp Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 263
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 263
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtagt 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 264
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 264
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ser Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 265
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 265
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgtattcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcactc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 266
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 266
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Val Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Thr Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 267
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 267
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa actgtgttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 268
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 268
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Val Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 269
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 269
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 270
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 270
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 271
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 271
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 272
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 272
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 273
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 273
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgctttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 274
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 274
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 275
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 275
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt tgcccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 276
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 276
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Cys Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 277
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 277
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 278
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 278
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 279
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 279
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt ctgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 280
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 280
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Leu Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 281
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 281
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gccgctttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 282
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 282
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 283
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 283
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 284
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 284
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 285
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 285
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 286
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 286
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 287
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 287
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 288
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 288
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 289
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 289
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 290
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 290
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 291
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 291
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgctttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 292
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 292
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 293
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 293
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 294
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 294
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 295
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 295
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt ctgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gccgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 296
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 296
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Leu Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 297
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 297
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 298
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 298
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 299
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 299
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt tgcccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 300
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 300
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Cys Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 301
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 301
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 302
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 302
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 303
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 303
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 304
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 304
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 305
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 305
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgtgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 306
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 306
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Val Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 307
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 307
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgtgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 308
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 308
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Val Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 309
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 309
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgtgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgctttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 310
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 310
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Val Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 311
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 311
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaatttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 312
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 312
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 313
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 313
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 314
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 314
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 315
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 315
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 316
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 316
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 317
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 317
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 318
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 318
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 319
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 319
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt tgcccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgtgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgctttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 320
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 320
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Cys Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Val Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 321
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 321
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcacttgc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcactg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gccggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caggtgaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcctgtgccg cgattgtact 1560
actaatcact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 322
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 322
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Cys Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Arg Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 323
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 323
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaatttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 324
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 324
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 325
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 325
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 326
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 326
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 327
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 327
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtggctttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 328
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 328
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gly Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 329
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 329
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtggcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 330
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 330
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gly Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 331
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 331
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg tagtccgggc 600
ggtattactg ctacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgta 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgctg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gccggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caggtgaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcctgtgccg cgattgtact 1560
cagaatcact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 332
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 332
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Ala Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ala Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Arg Asp Cys Thr Gln Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 333
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 333
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtac gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 334
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 334
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Thr Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 335
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 335
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 336
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 336
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 337
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 337
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtggcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 338
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 338
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gly Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 339
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 339
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtggcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 340
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 340
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gly Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 341
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 341
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgctttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 342
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 342
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 343
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 343
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 344
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 344
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 345
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 345
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtggcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 346
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 346
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gly Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 347
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 347
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 348
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 348
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 349
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 349
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgta 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gccggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caggtgaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 350
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 350
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 351
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 351
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaatttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 352
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 352
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 353
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 353
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt tgcccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgctttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 354
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 354
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Cys Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 355
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 355
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttcgcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcactg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg agcgcagtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcagaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg tgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 356
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 356
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Glu Arg Ser Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Met Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 357
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 357
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 358
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 358
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 359
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 359
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgta 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgctg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gccggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caggtgaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 360
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 360
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ala Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 361
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 361
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtggctttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 362
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 362
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gly Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 363
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 363
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactatg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaatttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 364
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 364
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Met Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 365
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 365
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 366
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 366
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 367
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 367
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 368
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 368
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 369
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 369
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaatttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 370
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 370
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 371
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 371
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 372
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 372
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 373
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 373
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactatg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgtgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 374
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 374
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Met Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Val Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 375
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 375
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaatttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 376
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 376
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 377
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 377
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt ctgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgctttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 378
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 378
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Leu Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 379
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 379
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgtgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaatttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 380
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 380
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Val Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 381
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 381
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 382
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 382
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 383
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 383
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt tgcccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactatg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 384
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 384
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Cys Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Met Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 385
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 385
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgtgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtggcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 386
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 386
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Val Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gly Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 387
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 387
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtactgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 388
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 388
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Thr 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 389
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 389
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt tgcccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgctttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 390
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 390
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Cys Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 391
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 391
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 392
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 392
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 393
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 393
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
atcgttacca aacacgacaa tttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgctg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gccggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caggtgaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 394
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 394
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Ile Val Thr Lys 
    210                 215                 220                 
His Asp Asn Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ala Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 395
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 395
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcacttgc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gccggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caggtgaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 396
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 396
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Cys Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 397
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 397
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgtgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgctttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 398
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 398
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Val Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 399
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 399
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 400
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 400
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 401
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 401
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggca gccggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caggtgaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcgtgtgcgg cgattgtact 1560
actaatcact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 402
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 402
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Ser Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Val Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 403
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 403
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt tgcccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 404
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 404
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Cys Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 405
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 405
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaatttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 406
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 406
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 407
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 407
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 408
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 408
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 409
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 409
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtactgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 410
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 410
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Thr 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 411
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 411
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gccggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caggtgaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcgtgtgcgg cgattgtact 1560
actaatcact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 412
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 412
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Val Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 413
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 413
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt tgcccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 414
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 414
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Cys Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 415
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 415
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactatg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaatttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 416
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 416
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Met Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 417
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 417
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgca tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 418
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 418
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Ile Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 419
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 419
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt tgcccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgtgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 420
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 420
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Cys Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Val Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 421
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 421
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtactgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactatg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 422
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 422
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Thr 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Met Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 423
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 423
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caggtgaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcctgtgcca cgattgtact 1560
cagaatcact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 424
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 424
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys His Asp Cys Thr Gln Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 425
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 425
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg tcgccctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcactg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg ggagcagtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcagaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 426
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 426
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Arg Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Ser Ser Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 427
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 427
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaatttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 428
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 428
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 429
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 429
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt tgcccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 430
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 430
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Cys Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 431
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 431
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgta 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gccggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caggtgaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcgtgtgccg cgattgtact 1560
cagaatcact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 432
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 432
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Val Cys Arg Asp Cys Thr Gln Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 433
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 433
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 434
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 434
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 435
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 435
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 436
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 436
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 437
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 437
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 438
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 438
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 439
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 439
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caatggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 440
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 440
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Met Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 441
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 441
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggca gccggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caggtgaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcctgtgcgg cgattgtact 1560
actaatcact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 442
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 442
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Ser Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 443
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 443
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggca gccggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagctgaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcctgtgcgg cgattgtact 1560
cagaatcact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 444
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 444
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Ser Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gln Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 445
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 445
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt tgcccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaatttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 446
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 446
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Cys Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 447
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 447
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg ggcgcagtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcagaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg tgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 448
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 448
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Ser Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Met Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 449
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 449
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 450
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 450
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 451
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 451
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtactgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtggcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 452
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 452
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Thr 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gly Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 453
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 453
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 454
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 454
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 455
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 455
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacaa tttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcactg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gccggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 456
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 456
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Asn Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 457
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 457
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cttttgaggg ttctcctggc 600
ggtattactc tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggca gccggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caggtgaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcgtgtgcgg cgattgtact 1560
actaatcact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 458
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 458
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Ser Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Val Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 459
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 459
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattactc tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgta 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgctg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gccggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagctgaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcgtgtgccg cgattgtact 1560
actaatcact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 460
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 460
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ala Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Val Cys Arg Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 461
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 461
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 462
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 462
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 463
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 463
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg tcgccctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg ggaactttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcagaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 464
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 464
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Arg Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Asn Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 465
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 465
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg tgcgcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg agcgcagtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcagaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg tgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 466
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 466
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ala Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Glu Arg Ser Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 467
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 467
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgtgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgctttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcggccgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 468
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 468
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Val Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 469
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 469
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacaa gtacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 470
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 470
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Ser Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 471
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 471
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcggttcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgtaa cgattgtacg 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 472
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 472
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Asn Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 473
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 473
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtactgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
actaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 474
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 474
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Thr 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 475
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 475
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtactgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 476
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 476
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Thr 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 477
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 477
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcgtgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaatttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 478
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 478
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Val Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 479
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 479
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtactgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgtt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcacgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtggcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 480
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 480
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Thr 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Val Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gly Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 481
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 481
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtactgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaatttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgttcggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc cagcggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 482
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 482
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Thr 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Phe Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Ala Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         


<210> 483
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 483
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gcgaggttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg tgattgtgct 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 484
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 484
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 485
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 485
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gcgaggttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg tgattgtact 1560
gggaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 486
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 486
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Gly Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 487
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 487
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcgaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 488
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 488
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 489
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 489
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caggtgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 490
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 490
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 491
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 491
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 492
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 492
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 493
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 493
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtacggttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 494
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 494
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 495
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 495
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaaccagtt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 496
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 496
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Ser Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 497
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 497
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgatacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 498
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 498
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 499
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 499
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgttataag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 500
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 500
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Tyr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 501
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 501
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 502
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 502
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 503
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 503
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 504
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 504
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 505
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 505
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 506
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 506
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 507
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 507
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacggcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 508
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 508
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ala Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 509
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 509
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactaccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accactacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 510
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 510
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Thr Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 511
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 511
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 512
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 512
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 513
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 513
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaggttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 514
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 514
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 515
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 515
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagg aggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 516
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 516
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Glu Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 517
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 517
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcaca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 518
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 518
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 519
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 519
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 520
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 520
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 521
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 521
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgttgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 522
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 522
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 523
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 523
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagg cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 524
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 524
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ala Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 525
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 525
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgatgg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 526
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 526
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Asp Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 527
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 527
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact gtccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 528
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 528
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Cys 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 529
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 529
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcacgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 530
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 530
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Thr Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 531
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 531
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc ctgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgtgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 532
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 532
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 533
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 533
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacagtgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 534
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 534
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 535
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 535
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
acctatacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 536
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 536
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Tyr Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 537
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 537
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgga ttcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 538
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 538
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Asp Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 539
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 539
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 540
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 540
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 541
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 541
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 542
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 542
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 543
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 543
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttcctttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 544
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 544
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Phe Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 545
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 545
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc aggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc caacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 546
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 546
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Gln Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 547
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 547
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgtgaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 548
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 548
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 549
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 549
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgtgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 550
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 550
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 551
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 551
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgtgagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 552
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 552
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 553
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 553
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaatccgga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 554
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 554
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 555
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 555
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 556
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 556
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 557
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 557
atggcatcag cgccgatcgg ggtggccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 558
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 558
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 559
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 559
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 560
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 560
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 561
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 561
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgagga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 562
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 562
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 563
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 563
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccacagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctggggagg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 564
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 564
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Glu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 565
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 565
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagccc atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 566
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 566
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala His Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 567
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 567
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcagt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 568
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 568
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 569
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 569
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga taacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 570
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 570
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 571
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 571
atggcatcac agccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 572
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 572
Met Ala Ser Gln Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 573
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 573
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgacat gtcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 574
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 574
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 575
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 575
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 576
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 576
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 577
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 577
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg agtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 578
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 578
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Glu Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 579
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 579
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccagacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 580
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 580
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gln Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 581
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 581
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gttcggttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 582
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 582
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Ser Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 583
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 583
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 584
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 584
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 585
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 585
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgctt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 586
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 586
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 587
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 587
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agtttctccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 588
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 588
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 589
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 589
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacactgcgt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggctgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 590
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 590
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Leu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 591
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 591
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc catttgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 592
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 592
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Phe Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 593
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 593
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 594
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 594
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 595
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 595
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgcgt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccttcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 596
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 596
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Phe Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 597
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 597
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 598
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 598
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 599
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 599
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggctgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc catttgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 600
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 600
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Leu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Phe Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 601
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 601
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggctgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 602
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 602
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Leu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 603
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 603
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgcgt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccttcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 604
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 604
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Phe Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 605
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 605
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacactgcgt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 606
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 606
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 607
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 607
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 608
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 608
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 609
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 609
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgcgt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 610
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 610
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 611
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 611
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 612
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 612
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 613
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 613
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggctgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 614
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 614
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Leu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 615
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 615
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 616
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 616
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 617
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 617
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccttcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 618
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 618
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Phe Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 619
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 619
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacactcaat atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgatgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccttcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 620
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 620
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Gln Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Asp Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Phe Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 621
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 621
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgcgt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 622
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 622
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 623
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 623
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggctgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 624
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 624
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Leu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 625
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 625
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 626
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 626
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 627
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 627
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc catttgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccttcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 628
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 628
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Phe Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Phe Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 629
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 629
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggctgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 630
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 630
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Leu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 631
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 631
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 632
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 632
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 633
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 633
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggctgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 634
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 634
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Leu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 635
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 635
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
acctacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc catttgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccttcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 636
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 636
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Tyr Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Phe Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Phe Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 637
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 637
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggctgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc catttgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccttcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 638
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 638
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Leu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Phe Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Phe Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 639
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 639
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc catttgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 640
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 640
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Phe Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 641
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 641
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc catttgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 642
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 642
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Phe Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 643
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 643
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgcgt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 644
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 644
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 645
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 645
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 646
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 646
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 647
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 647
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacactgcgt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgatgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 648
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 648
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Asp Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 649
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 649
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgcgt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 650
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 650
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 651
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 651
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggctgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 652
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 652
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Leu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 653
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 653
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccagg cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtactctgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 654
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 654
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ala Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Leu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 655
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 655
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggcggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgtgga gaagaacggg 900
gaggtttaca gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 656
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 656
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 657
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 657
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtagtgagga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 658
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 658
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Ser Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 659
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 659
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggagga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 660
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 660
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 661
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 661
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacagtgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 662
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 662
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 663
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 663
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggcggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc catttgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 664
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 664
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Phe Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 665
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 665
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgagga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 666
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 666
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 667
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 667
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggcggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgagga gaagaacggg 900
gaggtttact gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 668
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 668
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Glu Glu Lys Asn Gly Glu Val Tyr Cys 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 669
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 669
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 670
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 670
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 671
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 671
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtactgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 672
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 672
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 673
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 673
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggagga gaagaacggg 900
gaggtttact gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 674
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 674
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Glu Glu Lys Asn Gly Glu Val Tyr Cys 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 675
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 675
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgagga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 676
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 676
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 677
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 677
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacagtgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtactgagga gaagaacggg 900
gaggtttact gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 678
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 678
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Glu Glu Lys Asn Gly Glu Val Tyr Cys 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 679
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 679
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 680
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 680
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 681
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 681
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtagtgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 682
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 682
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Ser Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 683
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 683
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc catttgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 684
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 684
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Phe Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 685
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 685
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtactgagga gaagaacggg 900
gaggtttaca gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 686
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 686
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 687
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 687
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc catttgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgttgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 688
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 688
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Phe Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 689
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 689
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggcggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgagga gaagaacggg 900
gaggtttaca gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 690
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 690
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 691
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 691
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacagtgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggtgga gaagaacggg 900
gaggtttact gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 692
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 692
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Cys 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 693
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 693
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgagga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc catttgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 694
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 694
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Phe Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 695
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 695
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggcggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 696
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 696
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 697
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 697
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 698
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 698
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 699
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 699
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggcggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 700
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 700
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 701
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 701
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacagtgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 702
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 702
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 703
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 703
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 704
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 704
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 705
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 705
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 706
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 706
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 707
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 707
atggcatcag cgccgatcgg gatcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaagg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctggggaag gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgccgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaaccagtt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga taacggaggt 1800
aactcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 708
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 708
Met Ala Ser Ala Pro Ile Gly Ile Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Glu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Pro Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Ser Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 709
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 709
atggcatcag cgccgatcgg gatcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtacgaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgctaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgtagatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgatgg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgtcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgccgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccaat cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 710
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 710
Met Ala Ser Ala Pro Ile Gly Ile Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Asp Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Pro Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 711
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 711
atggcatcag cgccgatcgg gatcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgttaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgtagatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaagg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcactga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgccgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caggatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaaccagtt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgacag ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga taacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 712
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 712
Met Ala Ser Ala Pro Ile Gly Ile Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Thr Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Pro Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Ser Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 713
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 713
atggcatcag cgccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgctaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgtcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctggggaag gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgccgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
gacgatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaaccagtt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 714
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 714
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Glu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Pro Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Asp Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Ser Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 715
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 715
atggcatcag cgccgatcgg gatcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgctaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgtagatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaagg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctggggaag gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caggatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaaccagtt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgacat gtcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 716
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 716
Met Ala Ser Ala Pro Ile Gly Ile Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Glu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Ser Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 717
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 717
atggcatcag cgccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgatgg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctggggaag gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgccgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc catttgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccaat cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga taacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 718
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 718
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Asp Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Glu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Pro Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Phe Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 719
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 719
atggcatcag cgccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtacgaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgttaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgtagatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgatgg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgtcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctggggaag gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgccgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
gacgatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccaat cagtcaaggt cggcgggcgc 1680
atcaccattt caactgacat gtcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga taacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 720
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 720
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Asp Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Glu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Pro Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Asp Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 721
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 721
atggcatcag cgccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgttaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgatgg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gtggtgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcactga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc catttgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaaccagtt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa taacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 722
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 722
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Asp Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Trp Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Thr Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Phe Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Ser Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 723
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 723
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctacac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccaggcc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggacc 1680
atcaccattt caactgactc ttcaatctcg aaggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 724
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 724
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Ala Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Thr 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 725
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 725
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg ggtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 726
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 726
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Gly Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 727
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 727
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg agtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaaccagtt cagtcaaggt cggcgggacc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 728
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 728
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Glu Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Ser Ser Val Lys Val Gly Gly Thr 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 729
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 729
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaacgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggacc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 730
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 730
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Thr 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 731
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 731
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 732
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 732
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 733
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 733
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacactcaat atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 734
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 734
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 735
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 735
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 736
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 736
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 737
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 737
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccttcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 738
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 738
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Phe Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 739
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 739
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 740
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 740
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 741
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 741
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggctgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccttcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 742
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 742
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Glu Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Leu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Phe Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 743
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 743
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttactat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 744
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 744
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 745
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 745
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgcgt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
acctacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 746
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 746
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Tyr Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 747
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 747
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacactgcgt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgatgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 748
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 748
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Asp Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 749
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 749
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 750
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 750
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 751
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 751
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 752
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 752
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 753
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 753
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtgatgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccttcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 754
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 754
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Asp Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Phe Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 755
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 755
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacactgcgt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
acctacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 756
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 756
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Tyr Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 757
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 757
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccttcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 758
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 758
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Phe Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 759
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 759
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacactgcgt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggctgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 760
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 760
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Leu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 761
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 761
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 762
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 762
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 763
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 763
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacactcaat atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
acctacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggctgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 764
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 764
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Gln Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Tyr Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Leu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 765
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 765
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 766
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 766
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 767
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 767
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 768
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 768
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 769
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 769
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccttcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 770
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 770
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Phe Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 771
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 771
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggctgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 772
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 772
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Leu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 773
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 773
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggctgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccttcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 774
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 774
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Leu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Phe Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 775
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 775
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgcggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 776
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 776
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 777
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 777
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 778
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 778
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 779
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 779
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtgacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 780
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 780
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 781
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 781
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 782
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 782
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Cys 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 783
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 783
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacagtgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggagga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 784
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 784
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 785
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 785
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 786
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 786
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 787
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 787
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgagga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 788
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 788
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 789
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 789
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggcggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacagtgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtagtgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 790
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 790
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Ser Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 791
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 791
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacagtgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttaca gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 792
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 792
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 793
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 793
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggagga gaagaacggg 900
gaggtttact gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 794
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 794
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Glu Glu Lys Asn Gly Glu Val Tyr Cys 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 795
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 795
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttaca gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 796
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 796
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 797
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 797
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtagtgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 798
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 798
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Ser Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 799
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 799
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacagtgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 800
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 800
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 801
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 801
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggcggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacagtgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtactgtgga gaagaacggg 900
gaggtttact gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 802
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 802
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Val Glu Lys Asn Gly Glu Val Tyr Cys 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 803
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 803
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacagtgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 804
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 804
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 805
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 805
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 806
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 806
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Cys 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 807
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 807
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtagtgagga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 808
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 808
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Ser Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 809
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 809
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggcggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtactgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 810
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 810
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 811
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 811
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtactgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 812
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 812
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 813
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 813
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 814
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 814
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 815
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 815
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtagtgtgga gaagaacggg 900
gaggtttaca gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 816
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 816
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Ser Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 817
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 817
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtagtgtgga gaagaacggg 900
gaggtttaca gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 818
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 818
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Ser Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 819
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 819
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 820
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 820
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 821
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 821
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 822
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 822
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 823
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 823
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacagtgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtactgtgga gaagaacggg 900
gaggtttact gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 824
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 824
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Val Glu Lys Asn Gly Glu Val Tyr Cys 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 825
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 825
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggagga gaagaacggg 900
gaggtttact gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 826
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 826
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Glu Glu Lys Asn Gly Glu Val Tyr Cys 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 827
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 827
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtactgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 828
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 828
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 829
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 829
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 830
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 830
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 831
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 831
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 832
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 832
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 833
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 833
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 834
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 834
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Cys 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 835
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 835
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtgtttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 836
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 836
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Cys 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 837
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 837
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 838
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 838
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 839
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 839
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtactgagga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 840
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 840
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 841
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 841
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggtgga gaagaacggg 900
gaggtttaca gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 842
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 842
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 843
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 843
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggcggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtactgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 844
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 844
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 845
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 845
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcgcgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtagtgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 846
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 846
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Arg Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Ser Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 847
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 847
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacagtgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgattg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaggagga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 848
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 848
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ile Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 849
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 849
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttaca gcccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 850
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 850
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 851
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 851
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggagga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 852
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 852
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 853
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 853
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggagga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 854
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 854
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 855
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 855
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtactgagga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 856
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 856
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 857
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 857
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtagtgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 858
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 858
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Ser Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 859
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 859
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggagga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 860
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 860
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Glu Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 861
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 861
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaggtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccattagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 862
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 862
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 863
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 863
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actggagtgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgagtg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagc 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgtgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccgttagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 864
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 864
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Val Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 865
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 865
atggcatcag cgccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgttacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgctaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaagg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgccgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caggatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccaat cagtcaaggt cggcgggcgc 1680
atcaccattt caactgacag ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 866
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 866
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Tyr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Pro Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 867
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 867
atggcatcag cgccgatcgg gatcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgttacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgttaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgatgg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgtcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctggggaag gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
gacgatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaaccagtt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgacag ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 868
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 868
Met Ala Ser Ala Pro Ile Gly Ile Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Tyr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Asp Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Glu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Asp Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Ser Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 869
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 869
atggcatcag cgccgatcgg gatcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgtagatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgatgg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
gacgatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccaat cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga taacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 870
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 870
Met Ala Ser Ala Pro Ile Gly Ile Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Asp Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Asp Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 871
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 871
atggcatcag cgccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgctaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgtagatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaagg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctggggaag gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgccgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
gacgatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccaat cagtcaaggt cggcgggcgc 1680
atcaccattt caactgacag ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga taacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 872
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 872
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Glu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Pro Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Asp Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 873
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 873
atggcatcag cgccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgctaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaagg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcactga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctggggaag gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgccgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
gacgatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccaat cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa taacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 874
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 874
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Thr Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Glu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Pro Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Asp Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 875
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 875
atggcatcag cgccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtacgaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgctaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaagg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaaccagtt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa taacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 876
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 876
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Ser Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 877
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 877
atggcatcag cgccgatcgg gatcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaagg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctggggaag gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgccgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caggatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccaat cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 878
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 878
Met Ala Ser Ala Pro Ile Gly Ile Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Glu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Pro Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 879
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 879
atggcatcag cgccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtacgaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgttaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaagg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
gacgatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaaccagtt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga taacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 880
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 880
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Asp Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Ser Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 881
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 881
atggcatcag cgccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgctaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaagg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcactga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
gacgatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaaccagtt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgacat gtcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga taacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 882
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 882
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Thr Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Asp Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Ser Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 883
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 883
atggcatcag cgccgatcgg gatcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgtagatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgatgg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgccgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccaat cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga taacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 884
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 884
Met Ala Ser Ala Pro Ile Gly Ile Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Asp Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Pro Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 885
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 885
atggcatcag cgccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtacgaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgttaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgtagatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgatgg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgccgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
gacgatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccaat cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga taacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 886
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 886
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Asp Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Pro Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Asp Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 887
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 887
atggcatcag cgccgatcgg gatcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgctaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgatgg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgtcga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggagtg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
gacgatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaaccagtt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgacag ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 888
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 888
Met Ala Ser Ala Pro Ile Gly Ile Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Asp Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Asp Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Ser Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 889
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 889
atggcatcag cgccgatcgg gatcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttcggatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaagg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtttgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctggggaag gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgccgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
gacgatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaaccagtt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgacag ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 890
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 890
Met Ala Ser Ala Pro Ile Gly Ile Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Glu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Pro Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Asp Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Ser Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 891
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 891
atggcatcag cgccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctacac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaacgatg agtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtgcgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggacc 1680
atcaccattt caactgactc ttcaatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 892
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 892
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Glu Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Ala Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Thr 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 893
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 893
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 894
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 894
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 895
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 895
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg agtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccaggcc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggacc 1680
atcaccattt caactgactc ttcaatctcg aaggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 896
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 896
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Glu Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Ala Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Thr 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 897
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 897
atggcatcag cgccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaacgatg ggtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtgcgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 898
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 898
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Gly Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Ala Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 899
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 899
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgga ttcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggacc 1680
atcaccattt caactgactc ttcaatctcg aaggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 900
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 900
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Asp Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Thr 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 901
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 901
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg agtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtgcgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccaggcc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggacc 1680
atcaccattt caactgactc ttcaatctcg aaggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 902
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 902
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Glu Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Ala Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Ala Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Thr 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 903
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 903
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 904
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 904
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 905
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 905
atggcatcac aaccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg ggtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgaa ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 906
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 906
Met Ala Ser Gln Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Gly Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Asn Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 907
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 907
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 908
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 908
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 909
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 909
atggcatcag cgccgatcgg gtccgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 910
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 910
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 911
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 911
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg ggtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtgcgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 912
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 912
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Gly Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Ala Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 913
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 913
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg ggtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtgcgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggacc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 914
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 914
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Gly Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Ala Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Thr 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 915
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 915
atggcatcag cgccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg ggtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgaa ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtgcgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccaggcc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 916
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 916
Met Ala Ser Ala Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Gly Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Asn Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Ala Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Ala Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 917
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 917
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggacc 1680
atcaccattt caactgactc ttcaatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 918
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 918
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Thr 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 919
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 919
atggcatcac aaccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaacgatg agtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtgcgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 920
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 920
Met Ala Ser Gln Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Glu Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Ala Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 921
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 921
atggcatcac aaccgatcgg gagcgccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctacac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaacgatg ggtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccaat cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 922
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 922
Met Ala Ser Gln Pro Ile Gly Ser Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Gly Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 923
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 923
atggcatcac aaccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaacgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcgc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 924
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 924
Met Ala Ser Gln Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Arg Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 925
<211> 1959
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 925
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaacgatg ggtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaccg gtggtaatga tgcaaagaaa acttccttat atgattcgga ttcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccaggcc 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccaat cagtcaaggt cggcgggacc 1680
atcaccattt caactgactc ttcaatctcg aaggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
gggggcgggg gtagctggtc tcacccacag ttcgaaaag                        1959

 
<210> 926
<211> 653
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 926
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Gly Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Thr Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Asp Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Ala Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Thr 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys             
                645                 650                         

 
<210> 927
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 927
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 928
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 928
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 929
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 929
atggcatcac agccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 930
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 930
Met Ala Ser Gln Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 931
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 931
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagttc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 932
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 932
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 933
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 933
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgatgg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 934
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 934
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Asp Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 935
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 935
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccttcac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgccgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggctgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 936
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 936
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Leu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 937
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 937
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgcaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 938
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 938
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 939
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 939
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 940
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 940
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 941
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 941
atggcatcac agccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccttcac gatcgatatg 180
aaaacagttc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtactgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcaaggt cggcgggcgt 1680
atcaccattt caactgacat gtcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 942
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 942
Met Ala Ser Gln Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Phe Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 943
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 943
atggcatcac agccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgcaaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tgccgcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgatgg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggctgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 944
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 944
Met Ala Ser Gln Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Ala Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Asp Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Leu Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 945
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 945
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc gtcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 946
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 946
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 947
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 947
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc gtcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 948
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 948
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 949
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 949
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgcaaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc gtcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 950
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 950
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 951
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 951
atggcatcac agccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 952
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 952
Met Ala Ser Gln Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 953
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 953
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtactgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagcccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 954
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 954
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 955
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 955
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actggtcggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 956
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 956
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 957
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 957
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 958
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 958
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 959
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 959
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgaat atggtgccaa cggagatccc aaaccgccgc acaccgttac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 960
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 960
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Val Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 961
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 961
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actggtcggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 962
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 962
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 963
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 963
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 964
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 964
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 965
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 965
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccagt cggggaatga atgtactaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 966
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 966
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 967
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 967
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgaat atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 968
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 968
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 969
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 969
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtgctgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 970
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 970
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 971
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 971
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 972
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 972
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 973
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 973
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 974
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 974
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 975
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 975
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagtgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 976
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 976
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 977
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 977
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacactgcat atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 978
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 978
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 979
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 979
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggcggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 980
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 980
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 981
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 981
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgttacaag gcaattgacg gtaataagga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 982
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 982
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Tyr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 983
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 983
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 984
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 984
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 985
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 985
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgaat atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 986
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 986
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 987
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 987
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgttacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgaat atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 988
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 988
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Tyr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 989
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 989
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgaat atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 990
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 990
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 991
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 991
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtactaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 992
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 992
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 993
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 993
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgaat atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 994
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 994
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 995
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 995
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgttacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagtgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 996
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 996
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Tyr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 997
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 997
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccagt cggggaatga atgttacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 998
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 998
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Tyr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 999
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 999
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtactaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1000
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1000
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1001
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1001
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccagc cggggaatga atgttacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1002
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1002
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Tyr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1003
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1003
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgcat atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1004
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1004
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1005
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1005
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgttacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1006
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1006
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Tyr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1007
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1007
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actggtcggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1008
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1008
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1009
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1009
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgcat atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1010
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1010
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1011
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1011
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1012
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1012
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1013
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1013
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1014
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1014
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1015
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1015
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1016
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1016
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1017
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1017
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtactaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1018
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1018
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1019
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1019
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1020
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1020
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1021
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1021
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1022
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1022
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1023
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1023
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1024
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1024
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1025
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1025
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actggtcggt tacatgcgat 60
tccgcccaga gtgggaatga atgttacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1026
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1026
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Tyr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1027
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1027
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgaat atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1028
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1028
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1029
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1029
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtactaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgcat atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1030
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1030
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1031
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1031
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtactaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1032
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1032
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1033
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1033
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtactaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1034
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1034
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1035
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1035
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgttacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1036
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1036
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Tyr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1037
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1037
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtactaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1038
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1038
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1039
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1039
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccagc cggggaatga atgtactaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1040
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1040
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1041
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1041
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagtgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1042
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1042
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1043
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1043
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1044
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1044
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1045
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1045
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagtgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1046
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1046
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1047
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1047
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1048
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1048
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1049
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1049
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccagc cggggaatga atgtactaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1050
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1050
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1051
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1051
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccagt cggggaatga atgtactaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgaat atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1052
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1052
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1053
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1053
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1054
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1054
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1055
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1055
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1056
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1056
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1057
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1057
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataagga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1058
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1058
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1059
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1059
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actggtcggt tacatgcgat 60
tccgcccagt cggggaatga atgtactaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1060
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1060
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1061
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1061
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgcat atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1062
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1062
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1063
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1063
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaatccaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgatgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1064
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1064
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Asp Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1065
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1065
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtactaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagtgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1066
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1066
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1067
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1067
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtactaag gcaattgacg gtaataaaga cacgttttgg 120
cacactttct atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggc 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1068
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1068
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1069
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1069
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccagc cggggaatga atgtactaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgtcacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactacgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1070
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1070
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Thr Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1071
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1071
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggaggt tacatgcgat 60
tccgcccaga gtgggaatga atgtactaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtaatgatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgacacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1072
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1072
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Asn 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1073
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1073
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actggtcggt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgaat atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaagatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttcgtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cctgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1074
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1074
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ser 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Arg Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Leu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1075
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1075
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg tagccctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg ggcgcagtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat cgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caggcgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg tgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1076
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1076
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Ser Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1077
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1077
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg agcgcgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1078
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1078
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Glu Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1079
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1079
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca acgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag taatgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1080
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1080
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1081
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1081
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtcacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca acgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtacc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag taatgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1082
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1082
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys His Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1083
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1083
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag tgatgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc gtcaatctcg aaggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1084
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1084
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1085
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1085
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtcacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatgg tgatgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1086
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1086
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys His Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Gly Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1087
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1087
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca acgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaaaaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1088
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1088
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1089
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1089
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1090
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1090
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1091
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1091
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca acgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatgg taatgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc gtcaatctcg aaggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1092
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1092
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Gly Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1093
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1093
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1094
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1094
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1095
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1095
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtacc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag tgatgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1096
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1096
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1097
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1097
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtcacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca acgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtacc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgacat gtcaatctcg aaggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1098
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1098
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys His Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1099
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1099
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtcacaag gcaattgacg gtaataagga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag tgatgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1100
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1100
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys His Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1101
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1101
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagccg cggggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1102
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1102
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Ala Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1103
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1103
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtcacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtacc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1104
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1104
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys His Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1105
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1105
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaatgttga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca acgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatgg tgatgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc gtcaatctcg aaggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1106
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1106
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Val Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Gly Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1107
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1107
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaatgttga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagccg cggggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtacc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caatgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1108
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1108
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Val Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Ala Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1109
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1109
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtcacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagccg cggggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaaaaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatgg tgatgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1110
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1110
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys His Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Ala Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Gly Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1111
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1111
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtcacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1112
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1112
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys His Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1113
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1113
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaatgttga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagccg cggggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatgg tgatgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1114
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1114
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Val Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Ala Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Gly Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1115
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1115
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtacc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1116
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1116
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1117
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1117
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1118
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1118
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1119
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1119
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca acgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag taatgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc gtcaatctcg aaggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1120
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1120
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1121
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1121
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagccg cggggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1122
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1122
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Ala Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1123
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1123
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca acgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1124
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1124
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1125
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1125
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtcacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagccg cggggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1126
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1126
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys His Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Ala Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1127
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1127
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca acgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaaaaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatgg tgatgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1128
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1128
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Gly Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1129
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1129
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatcgtt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1130
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1130
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Arg Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1131
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1131
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccaaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc tgagatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1132
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1132
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Glu Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1133
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1133
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttaccctca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1134
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1134
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Pro Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1135
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1135
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgctgt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1136
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1136
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Ala Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1137
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1137
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgttgt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1138
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1138
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1139
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1139
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc tccgatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1140
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1140
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Pro Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1141
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1141
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt ggactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1142
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1142
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1143
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1143
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggagaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1144
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1144
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Glu Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1145
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1145
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caggggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1146
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1146
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1147
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1147
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattg atactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1148
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1148
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Asp Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1149
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1149
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattg agactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1150
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1150
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Glu Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1151
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1151
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccggatgac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1152
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1152
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Asp Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1153
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1153
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgggga atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1154
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1154
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Gly Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1155
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1155
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg atcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1156
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1156
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Asp 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1157
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1157
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccatta ctactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1158
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1158
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Thr Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1159
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1159
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaagggg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1160
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1160
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Gly Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1161
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1161
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcagtgt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1162
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1162
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Ser Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1163
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1163
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc gtcaatctcg aaggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1164
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1164
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1165
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1165
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaatgttga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaaaaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcc 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1166
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1166
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Val Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1167
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1167
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgaaggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1168
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1168
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1169
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1169
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1170
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1170
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1171
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1171
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcgatattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1172
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1172
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Asp Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1173
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1173
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagataggt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1174
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1174
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Arg Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1175
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1175
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc tgatatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1176
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1176
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Asp Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1177
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1177
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1178
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1178
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1179
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1179
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc tccgatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1180
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1180
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Pro Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1181
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1181
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtcg ctggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1182
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1182
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Ala Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1183
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1183
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcacggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1184
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1184
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Thr Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1185
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1185
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg tagccctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg agcgcgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caggcgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1186
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1186
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Glu Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Met Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1187
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1187
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg tagccctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactatg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg agcgcgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caggcgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg tgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1188
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1188
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Met Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Glu Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1189
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1189
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg tagccctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactgag 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg agcgcagtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtcaggata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caaccgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg tgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1190
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1190
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Glu Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Glu Arg Ser Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Gln Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1191
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1191
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg tagccctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg ggcgcgtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatgt ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caggcgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg tgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1192
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1192
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Val Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1193
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1193
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgctacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1194
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1194
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Ala Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1195
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1195
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacagcgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttctggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1196
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1196
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Ala Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Leu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1197
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1197
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtca tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1198
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1198
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1199
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1199
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatc gttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1200
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1200
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Arg Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1201
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1201
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgcggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1202
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1202
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Ala Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1203
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1203
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg tactcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtgat ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1204
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1204
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Thr Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Ile Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1205
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1205
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagca gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1206
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1206
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gln Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1207
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1207
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1208
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1208
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1209
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1209
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttagggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1210
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1210
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Arg Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1211
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1211
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttcttgg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1212
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1212
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Leu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1213
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1213
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatt ggtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1214
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1214
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Trp Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1215
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1215
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcggt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1216
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1216
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Gly Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1217
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1217
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1218
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1218
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ala Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1219
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1219
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaacg tggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1220
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1220
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Arg Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1221
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1221
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg tgggcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1222
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1222
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Gly Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1223
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1223
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagttg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1224
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1224
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Val Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1225
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1225
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttggggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1226
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1226
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Gly Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1227
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1227
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagcgcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1228
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1228
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ala Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1229
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1229
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcgcg ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1230
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1230
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ala Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1231
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1231
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttcgggggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1232
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1232
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Gly Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1233
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1233
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttcaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1234
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1234
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Gln Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1235
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1235
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgtggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1236
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1236
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Val Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1237
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1237
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttattgg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1238
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1238
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Ile Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1239
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1239
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg tttttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1240
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1240
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Val Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1241
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1241
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg tacgcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1242
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1242
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Thr Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1243
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1243
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1244
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1244
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1245
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1245
atggcatcag cgccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acaccattac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaagcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcgcgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtccg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggcgc 1680
atcaccattt caactgactc ttcaatctcg aaagcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1246
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1246
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Glu Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Arg Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Arg 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Ser Ser Ile Ser Lys Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1247
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1247
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggaagt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgctt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagttc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaagg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactatg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg ggcaggttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caaccgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag cgatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1248
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1248
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Met Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1249
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1249
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggaagt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaagg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcacttcg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg ggcaggttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaatccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caggtgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag cgatgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1250
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1250
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Glu 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1251
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1251
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggcagt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgctt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaagg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcacttcg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg ggcaggttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat cgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caggtgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag cgatgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1252
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1252
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Ala Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1253
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1253
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggcagt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagttc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactatg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg agagtgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatat cgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caggtgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag cgatgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1254
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1254
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Met Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Glu Ser Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Ile Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1255
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1255
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggcagt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagttc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcacttcg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg ggcaggttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caaccgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag cgatgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1256
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1256
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1257
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1257
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggcagt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagttc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaagg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatac gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctctggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1258
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1258
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Thr Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1259
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1259
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggcagt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaagg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcacttcg 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg ggcaggttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttagtccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caggtgaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caatgggaac 1620
ttagccactc gccctaaaat cacctggacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattct ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1260
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1260
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Ser Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Trp Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Leu Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1261
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1261
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggagaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaggcg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattg atactgacat gccgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccggatgac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1262
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1262
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Glu Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Gly Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Asp Thr Asp Met Pro Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Asp Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1263
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1263
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1264
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1264
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1265
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1265
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagttc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1266
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1266
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1267
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1267
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt caactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1268
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1268
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1269
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1269
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagttc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggagaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccggatgac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1270
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1270
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Glu Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Asp Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1271
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1271
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaactc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1272
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1272
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1273
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1273
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt taagtgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagttc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagccg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1274
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1274
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Lys Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1275
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1275
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtcc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgatacca aacacgacat gttttgcccc ggtatctcga tggacgggaa tggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcg 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1276
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1276
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1277
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1277
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtcc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgatacca aacacgacat gttttgcccc ggtatctcga tggacgggaa tggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcg 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1278
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1278
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1279
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1279
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtcc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgatacca aacacgacat gttttgcccc ggtatctcga tggacgggga tggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtacg 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caatgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1280
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1280
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1281
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1281
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcagt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtcc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgatacca aacacgacat gttttgcccc ggtatctcga tggacgggga tggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1282
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1282
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1283
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1283
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcagt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtcc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga tggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1284
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1284
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1285
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1285
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagttc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga tggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gctcggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtacg 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1286
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1286
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Ser Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1287
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1287
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagttc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgatacca aacacgacat gttttgcccc ggtatctcga tggacgggga tggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgcg 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag cgatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1288
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1288
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Asp Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1289
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1289
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagttc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggacgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccagcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatc gctttgaggg ttcgcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cctggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgctgcc gaatacggta tttgcgagca atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcaaggt cggcgggtgg 1680
atcaccattt caactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1290
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1290
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Thr Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ala Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Arg Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Leu Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Leu Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Lys Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Ser Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1291
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1291
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1292
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1292
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1293
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1293
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1294
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1294
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1295
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1295
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg agcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1296
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1296
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Glu Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1297
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1297
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcagt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1298
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1298
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1299
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1299
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg ggcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag cgatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga cgagggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1300
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1300
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1301
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1301
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg agcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag cgatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1302
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1302
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Glu Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1303
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1303
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1304
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1304
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1305
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1305
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg ggcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccggtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa cgagggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1306
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1306
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Gly Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Glu Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1307
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1307
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg ggcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag cgatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1308
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1308
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1309
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1309
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactgagt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1310
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1310
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Glu Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1311
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1311
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcagt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggga cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg ggcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgct 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag cgatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgga caatggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1312
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1312
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asp Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Ala Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asp Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1313
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1313
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc ccgccgccgc actggatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc cagacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgccg agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttat tagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatacgt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattg acactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1314
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1314
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Pro Pro Pro His Trp Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Gln Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Pro Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Ile Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Asp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1315
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1315
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttat tagtgcaggg gatcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattg acactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttgc agttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1316
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1316
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Ile Ser 
        355                 360                 365             
Ala Gly Asp Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Asp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Gln Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1317
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1317
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt taagtgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggaaaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg tagccctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaacg cggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc cgacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat catgcgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1318
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1318
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Lys Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Glu Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Arg Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Met Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1319
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1319
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacgtgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggaaaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg tagccctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaacg cggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc cgacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat catgcgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1320
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1320
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Glu Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Arg Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Met Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1321
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1321
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ccatgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1322
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1322
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser His Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1323
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1323
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gtttagcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1324
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1324
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Ser Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1325
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1325
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg gctcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1326
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1326
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Ala Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1327
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1327
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcaagg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1328
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1328
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Lys Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1329
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1329
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaggaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1330
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1330
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Arg Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1331
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1331
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgaagattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1332
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1332
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Lys Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1333
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1333
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aagacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga taacacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1334
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1334
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Asn Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1335
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1335
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca tgtttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1336
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1336
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Met Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1337
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1337
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccgagacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1338
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1338
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Glu Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1339
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1339
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat ggcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1340
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1340
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ala Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1341
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1341
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg ccgcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1342
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1342
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Pro Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1343
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1343
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggagtaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1344
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1344
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Ser Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1345
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1345
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt gtgtccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1346
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1346
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Val Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1347
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1347
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataatga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1348
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1348
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Asn Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1349
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1349
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcttggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg actacgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacga atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1350
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1350
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Thr Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1351
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1351
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttctgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtgatg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1352
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1352
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Asp Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1353
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1353
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg gtcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1354
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1354
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1355
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1355
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtaat 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1356
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1356
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Asn Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1357
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1357
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgg ggggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1358
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1358
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Gly 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1359
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1359
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
gaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1360
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1360
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Glu Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1361
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1361
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acatgatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1362
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1362
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Met Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1363
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1363
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatcaag gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1364
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1364
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Lys Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1365
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1365
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1366
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1366
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1367
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1367
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccatta agactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtacg gttttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1368
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1368
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Lys Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Gly Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1369
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1369
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1370
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1370
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1371
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1371
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtacggttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1372
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1372
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1373
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1373
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacatcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1374
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1374
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1375
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1375
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacgg gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1376
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1376
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Gly Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1377
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1377
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atcgaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1378
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1378
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Ser Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1379
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1379
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgatttg ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1380
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1380
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Trp Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1381
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1381
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgcaaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat gtgcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1382
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1382
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Val Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1383
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1383
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aagccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc ctcctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1384
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1384
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Pro 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1385
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1385
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaatcgg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1386
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1386
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Ser Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1387
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1387
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc accgtatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgtactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1388
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1388
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Arg Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1389
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1389
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga acctaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1390
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1390
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Pro Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1391
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1391
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcttgg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1392
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1392
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Leu Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1393
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1393
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt ttttaaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1394
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1394
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Leu Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1395
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1395
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atagggcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1396
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1396
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn Arg Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1397
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1397
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttgt gtttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1398
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1398
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Cys Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1399
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1399
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa actggtttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1400
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1400
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Gly Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1401
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1401
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg tcgccctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1402
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1402
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Arg Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1403
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1403
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttagggaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1404
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1404
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Gly Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1405
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1405
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga acctaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1406
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1406
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Pro Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1407
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1407
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1408
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1408
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1409
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1409
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga acctaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatcagt gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1410
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1410
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Pro Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1411
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1411
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggcccgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatcagt gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1412
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1412
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Pro Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1413
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1413
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtacg 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatcagt gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1414
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1414
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1415
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1415
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1416
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1416
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1417
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1417
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
gaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaagtg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1418
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1418
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Glu Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Ser Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1419
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1419
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaagtg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtacg 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1420
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1420
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Ser Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1421
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1421
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaaag gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatcagt gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1422
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1422
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1423
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1423
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaagtg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1424
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1424
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Ser Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1425
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1425
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgatttg ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1426
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1426
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Trp Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1427
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1427
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acacgatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagtgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtactgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggtcgaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat ggcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga ccttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1428
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1428
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Ser Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ala Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1429
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1429
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagtgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttgt gtttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1430
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1430
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Cys Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1431
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1431
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc accgtatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat ggcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga ccttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1432
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1432
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Arg Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ala Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1433
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1433
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acacgatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggtcgaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat ggcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga ccttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1434
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1434
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Ser Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ala Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1435
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1435
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggtcgaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttgt gtttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1436
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1436
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Ser Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Cys Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1437
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1437
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc accgtatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagtgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat ggcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga ccttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgatttg ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1438
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1438
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Arg Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ala Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Trp Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1439
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1439
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc accgtatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat ggcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttgt gtttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1440
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1440
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Arg Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ala Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Cys Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1441
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1441
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat ggcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga ccttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgatttg ggttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1442
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1442
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ala Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Trp Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1443
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1443
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc accgtatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagtgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggtcgaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gttttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1444
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1444
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Arg Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Ser Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1445
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1445
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagtgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtactgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggtcgaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga ccttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1446
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1446
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Ser Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1447
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1447
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc accgtatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggaagccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacca aacacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagtgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtactgttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttctctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtact 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga ccttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattcg tgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1448
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1448
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Arg Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Lys 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Thr Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Thr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Arg Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1449
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1449
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatg gttcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1450
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1450
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gly Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1451
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1451
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgggcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1452
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1452
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Gly Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1453
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1453
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttatt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1454
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1454
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1455
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1455
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttatg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1456
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1456
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Cys Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1457
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1457
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccggtgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1458
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1458
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Val Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1459
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1459
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatgtggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1460
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1460
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Val Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1461
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1461
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1462
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1462
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1463
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1463
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggttccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1464
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1464
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1465
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1465
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatccgtg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1466
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1466
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Pro 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1467
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1467
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt cattgcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1468
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1468
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Leu Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1469
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1469
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gccttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1470
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1470
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Leu Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1471
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1471
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtgataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1472
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1472
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asp Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1473
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1473
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccgttt atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaaaaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1474
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1474
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Val Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1475
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1475
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcaacta aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1476
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1476
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Thr Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1477
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1477
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
tctaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1478
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1478
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ser Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1479
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1479
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca actgccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1480
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1480
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Leu Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1481
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1481
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg atatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1482
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1482
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Asp Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1483
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1483
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctgcg 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1484
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1484
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Ala Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1485
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1485
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggcgttggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1486
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1486
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Arg Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1487
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1487
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cctgcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1488
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1488
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Leu Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1489
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1489
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccag gggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1490
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1490
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Arg Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1491
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1491
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atgttgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1492
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1492
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Val Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1493
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1493
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gaagatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1494
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1494
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Lys Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1495
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1495
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcaggta aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1496
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1496
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Gly Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1497
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1497
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccat 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1498
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1498
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala His Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1499
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1499
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactc atccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1500
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1500
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr His Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1501
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1501
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1502
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1502
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1503
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1503
atggcatcag caccgatcgg ggtagccatc ccgcgccata actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1504
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1504
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg His Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1505
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1505
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtatgatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1506
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1506
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Met Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1507
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1507
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgtggacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1508
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1508
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Trp Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1509
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1509
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgggggcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1510
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1510
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Gly Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1511
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1511
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattttaca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1512
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1512
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Phe Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1513
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1513
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gaagctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1514
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1514
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Lys Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1515
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1515
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata attcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1516
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1516
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1517
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1517
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagata aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1518
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1518
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Asp Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1519
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1519
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacacgaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1520
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1520
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Thr Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1521
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1521
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtactt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1522
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1522
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Thr Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1523
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1523
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttacg gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1524
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1524
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Arg Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1525
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1525
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccgg 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1526
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1526
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Arg Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1527
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1527
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
attgtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1528
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1528
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Ile Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1529
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1529
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcaccta aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1530
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1530
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Pro Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1531
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1531
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccctt 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1532
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1532
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Leu Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1533
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1533
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaat gacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1534
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1534
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Met Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1535
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1535
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaata tacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1536
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1536
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Tyr Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1537
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1537
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtacta cgatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1538
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1538
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Thr Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1539
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1539
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta catgcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1540
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1540
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Met Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1541
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1541
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattagtg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1542
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1542
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1543
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1543
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1544
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1544
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1545
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1545
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaat tacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1546
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1546
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Ile Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1547
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1547
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgcggtta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1548
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1548
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Arg Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1549
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1549
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata ttcggctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1550
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1550
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Ser Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1551
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1551
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
acgaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1552
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1552
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Thr Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1553
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1553
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
agggccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1554
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1554
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Arg Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1555
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1555
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gaggctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1556
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1556
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Arg Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1557
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1557
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1558
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1558
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Gly Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1559
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1559
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaccccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1560
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1560
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Thr Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1561
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1561
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtagt tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1562
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1562
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Ser Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1563
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1563
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1564
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1564
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1565
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1565
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gttgctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1566
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1566
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Leu Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1567
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1567
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatcccc tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1568
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1568
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Pro Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1569
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1569
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
atttttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1570
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1570
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Ile Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1571
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1571
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccaag 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1572
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1572
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1573
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1573
atggcatcag caccgatcgg ggtagccatc ccgcgcgcca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccggttcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggttccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgggtgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatgtagta tttgcgagta atgggttagt cttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1574
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1574
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Ala Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Val Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Gly Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Val Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1575
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1575
atggcatcag caccgatcgg ggtagccatc ccgcgcaata actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttgt atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatg ggtcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtatttcaca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1576
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1576
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gly Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Phe Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1577
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1577
atggcatcag caccgatcgg ggtagccatc ccgcgcaata actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggttccgg gcccggatat gcaggtcgcg cgtgggtatg ggtcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaacgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattacaca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttacg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
attaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1578
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1578
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gly Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Arg Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1579
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1579
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatg ggtcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaacgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt cttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gaagatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1580
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1580
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gly Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Lys Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1581
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1581
atggcatcag caccgatcgg ggtagccatc ccgcgcgcca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatg ggtcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1582
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1582
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Ala Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gly Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1583
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1583
atggcatcag caccgatcgg ggtagccatc ccgcgcaata actgggccgt tacatgcgat 60
tccgcccaga gtgggatgga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggttccgg gcccggatat gcaggtcgcg cgtgggtatg ggtcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgggtgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttacg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1584
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1584
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Met Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gly Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Gly Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Arg Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1585
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1585
atggcatcag caccgatcgg ggtagccatc ccgcgcaata actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccggttcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatg ggtcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgggtgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatactgta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
attaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaggt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1586
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1586
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Val Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gly Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Gly Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1587
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1587
atggcatcag caccgatcgg ggtagccatc ccgcgcgcca actgggccgt tacatgcgat 60
tccgcccaga gtgggatgga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccggttcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatg ggtcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaacgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtatttcaca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatgtagta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
attaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1588
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1588
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Ala Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Met Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Val Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gly Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Phe Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Val Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1589
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1589
atggcatcag caccgatcgg ggtagccatc ccgcgcaata actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggttccgg gcccggatat gcaggtcgcg cgtgggtatg ggtcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgggtgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtga aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
attaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaggt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1590
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1590
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gly Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Gly Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1591
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1591
atggcatcag caccgatcgg ggtagccatc ccgcgcgcca actgggccgt tacatgcgat 60
tccgcccaga gtgggaacga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggttccgg gcccggatat gcaggtcgcg cgtgggtatg ggtcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgggtgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatactgta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1592
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1592
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Ala Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gly Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Gly Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1593
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1593
atggcatcag caccgatcgg ggtagccatc ccgcgcgcca actgggccgt tacatgcgat 60
tccgcccaga gtgggaacga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatg ggtcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaacgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttaaa attcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
attaccattt ggactgacat gaagatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttagcgt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1594
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1594
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Ala Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gly Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Lys Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Lys Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Ser Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1595
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1595
atggcatcag caccgatcgg ggtagccatc ccgcgcgcca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatg ggtcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgggtgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt cttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1596
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1596
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Ala Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gly Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Gly Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1597
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1597
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1598
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1598
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1599
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1599
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggg 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtactt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgctgacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1600
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1600
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Thr Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1601
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1601
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtactt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1602
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1602
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Thr Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1603
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1603
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggttccgg gcccggatat gcaggtcgcg cgtgggtatc agtcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccct 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1604
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1604
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1605
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1605
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc agtcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccct 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
cgtgccactc gccctaaaat cacccgtact tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1606
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1606
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Arg Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1607
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1607
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acactatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggttccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgtggacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1608
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1608
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Trp Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1609
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1609
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggttccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccat 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ctggccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1610
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1610
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala His Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1611
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1611
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggttccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1612
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1612
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1613
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1613
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gcgcctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccct 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttatg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1614
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1614
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Arg Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Cys Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1615
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1615
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggttccgg gcccggatat gcaggtcgcg cgtgggtatc agtcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtta aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
cgtgccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1616
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1616
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Arg Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1617
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1617
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggttccgg gcccggatat gcaggtcgcg cgtgggtatc agtcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtactt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgtgcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ctggccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgtggacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1618
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1618
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Thr Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Trp Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1619
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1619
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggttccgg gcccggatat gcaggtcgcg cgtgggtatc agtcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggcctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca actgccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1620
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1620
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Leu Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1621
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1621
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1622
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1622
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1623
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1623
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggg 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtactt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtact tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgtggacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1624
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1624
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Thr Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Trp Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1625
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1625
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccat 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttatg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ctggccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1626
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1626
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala His Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Cys Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1627
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1627
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggg 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccct 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
gaccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1628
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1628
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Asp Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1629
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1629
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggg 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtactt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttatg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1630
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1630
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Thr Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Cys Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1631
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1631
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atgttgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggttccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggcctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtactt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttatg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtact tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgctgacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat agg                              1953

 
<210> 1632
<211> 651
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1632
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Val Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Thr Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Cys Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His Arg                     
                645                 650                         

 
<210> 1633
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1633
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggttccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccat 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtta aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ctggccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1634
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1634
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala His Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1635
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1635
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccag gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcaccaa aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtact tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1636
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1636
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Pro Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1637
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1637
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggg 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggcctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccat 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ctggccactc gccctaaaat cacccgtact tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgctgacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1638
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1638
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala His Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1639
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1639
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggttccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttatg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1640
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1640
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Cys Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1641
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1641
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggcctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
cgtgccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgctgacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1642
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1642
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Arg Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1643
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1643
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttacct ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acttttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1644
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1644
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Trp 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1645
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1645
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtactta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatttcgg gcccggatat gcaggtcgcg cgtgggtata attcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccccg 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1646
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1646
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1647
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1647
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatttcgg gcccggatat gcaggtcgcg cgtgggtata attcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca ggggctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccctg 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1648
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1648
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Leu Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1649
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1649
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccgc gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatttcgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggctgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1650
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1650
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1651
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1651
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata attcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gctgctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1652
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1652
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Leu Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1653
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1653
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtacta cgatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1654
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1654
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Thr Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1655
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1655
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtactta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatcccc gcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata attcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca ggggctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg cgatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta catgcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1656
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1656
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Pro Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Met Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1657
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1657
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtactta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca ggggctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccccg 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta catgcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggctgg 1680
accaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1658
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1658
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Met Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Thr Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1659
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1659
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtactta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatcccc gcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca ggggctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccctg 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1660
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1660
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Pro Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Leu Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1661
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1661
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaat gacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgcgctta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata attcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca ggggctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1662
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1662
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Met Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Arg Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1663
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1663
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgcgctta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata attcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccgc 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggctgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1664
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1664
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Arg Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Arg Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1665
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1665
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaata cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtactta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatttcgg gcccggatat gcaggtcgcg cgtgggtata attcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca ggggctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg cgatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagctgg 1680
accaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1666
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1666
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Tyr Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Thr Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1667
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1667
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaagt cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtactta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgtgcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1668
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1668
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Val Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1669
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1669
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata attcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca ggggctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtacta cgatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acttttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1670
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1670
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Thr Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1671
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1671
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtactta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatcccc gcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata attcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca ggggctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgtgcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggctgg 1680
accaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1672
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1672
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Pro Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Thr Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1673
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1673
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatcccc gcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtacta cgatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acttttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1674
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1674
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Pro Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Thr Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1675
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1675
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagctgg 1680
accaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1676
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1676
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Thr Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1677
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1677
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtactta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatttcgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca ggggctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
atttttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1678
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1678
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Ile Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1679
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1679
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata attcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccgc 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
atttttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agcatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1680
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1680
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Arg Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Ile Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1681
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1681
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaat gacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgcgctta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca ggggctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1682
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1682
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Met Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Arg Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1683
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1683
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata attcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1684
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1684
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1685
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1685
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatcccc gcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccgc 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1686
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1686
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Pro Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Arg Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1687
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1687
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtactta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatttcgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtacta cgatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagctgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1688
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1688
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Thr Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1689
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1689
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata attcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca ggggctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccgc 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acttttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagctgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1690
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1690
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Arg Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1691
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1691
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgcgctta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatttcgg gcccggatat gcaggtcgcg cgtgggtatc aatcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagctgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1692
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1692
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Arg Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Gln Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1693
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1693
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgcgctta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatttcgg gcccggatat gcaggtcgcg cgtgggtata attcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca ggggctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccgc 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1694
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1694
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Arg Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Arg Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1695
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1695
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgcgctta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatttcgg gcccggatat gcaggtcgcg cgtgggtata attcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca ggggctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1696
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1696
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Arg Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1697
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1697
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatttcgg gcccggatat gcaggtcgcg cgtgggtata attcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca ggggctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcagt caaatcgcgg agtagcccgc 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1698
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1698
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Arg Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1699
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1699
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacactc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccgcct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1700
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1700
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Leu Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ala Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1701
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1701
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccgcct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1702
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1702
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ala Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1703
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1703
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgtaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacacttttt atggtgccaa cggagatccc aaaccgccgc acacctatac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggcccgc ccgattatga ggattcagac gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccgcct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1704
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1704
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Phe Tyr Gly Ala Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Tyr Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Pro Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ala Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1705
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1705
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
gatcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1706
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1706
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Asp Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1707
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1707
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1708
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1708
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1709
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1709
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttatg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1710
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1710
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Cys Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1711
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1711
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1712
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1712
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1713
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1713
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtcccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
gatcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1714
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1714
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Asp Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1715
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1715
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1716
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1716
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1717
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1717
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagac gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttatg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
gatcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1718
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1718
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Cys Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Asp Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1719
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1719
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatcccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1720
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1720
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1721
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1721
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttatg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1722
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1722
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Cys Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1723
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1723
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatcccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1724
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1724
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1725
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1725
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagac gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1726
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1726
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1727
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1727
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg gttcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgactattaa cgttacccag 1920
gatcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1728
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1728
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Asp Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1729
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1729
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatcccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1730
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1730
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1731
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1731
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccgcct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1732
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1732
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ala Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1733
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1733
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtcccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagac gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttatg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
gatcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1734
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1734
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Cys Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Asp Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1735
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1735
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccgcct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1736
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1736
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ala Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1737
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1737
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttatg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1738
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1738
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Cys Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1739
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1739
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtcccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagac gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1740
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1740
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1741
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1741
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatcccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1742
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1742
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1743
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1743
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1744
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1744
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1745
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1745
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
gatcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1746
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1746
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Asp Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1747
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1747
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatcccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttacg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1748
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1748
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Arg Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1749
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1749
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag atcggactct 780
tgggtctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1750
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1750
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Arg Ser Asp Ser Trp Val Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1751
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1751
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttacg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccgcct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
gatcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1752
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1752
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Arg Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ala Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Asp Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1753
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1753
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttatg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tctgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1754
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1754
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Cys Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1755
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1755
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1756
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1756
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1757
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1757
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatcccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccgcct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
gatcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1758
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1758
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ala Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Asp Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1759
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1759
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttatg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1760
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1760
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Cys Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1761
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1761
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1762
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1762
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1763
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1763
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttacg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccgcct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1764
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1764
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Arg Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ala Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1765
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1765
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatcccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttacg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1766
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1766
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Arg Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1767
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1767
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1768
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1768
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1769
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1769
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtcccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgtgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1770
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1770
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1771
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1771
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1772
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1772
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1773
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1773
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatcccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagac gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttatg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1774
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1774
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Cys Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1775
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1775
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1776
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1776
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1777
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1777
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatcccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccgcct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1778
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1778
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ala Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1779
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1779
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtcccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1780
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1780
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1781
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1781
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagac gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1782
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1782
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1783
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1783
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggatctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1784
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1784
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1785
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1785
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggtcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1786
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1786
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1787
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1787
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1788
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1788
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1789
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1789
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtcccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1790
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1790
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1791
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1791
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1792
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1792
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1793
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1793
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacgag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1794
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1794
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Glu Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1795
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1795
atggcatcag caccgatcgg ggtagccatc ccgcgcaaga actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggacaccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagccaaa 1140
gacgctatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagt gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccgcct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
gatcaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1796
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1796
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Lys Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly His Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Lys Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Val Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ala Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Asp Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1797
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1797
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tgggtctcgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttatg tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcagttgg 1680
atcaccatct ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1798
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1798
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Val Ser Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Cys Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Ser Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1799
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1799
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggtctgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1800
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1800
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Ser Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1801
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1801
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctattccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1802
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1802
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Ile Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1803
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1803
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttac ttgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1804
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1804
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Leu Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1805
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1805
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccggggcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1806
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1806
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Gly Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1807
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1807
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgct gggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1808
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1808
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Leu Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1809
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1809
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcact tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1810
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1810
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Leu Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1811
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1811
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggatcgggat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1812
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1812
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Arg Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1813
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1813
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcaagttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1814
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1814
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Lys 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1815
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1815
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggatcatgat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1816
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1816
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp His Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1817
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1817
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atttgaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1818
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1818
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Phe 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1819
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1819
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
ggttcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1820
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1820
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Gly Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1821
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1821
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcagcgttct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1822
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1822
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Arg Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1823
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1823
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgatg 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1824
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1824
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Met Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1825
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1825
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgtcgtg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1826
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1826
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Ser Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1827
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1827
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggtg agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1828
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1828
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Val Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1829
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1829
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaagatgtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1830
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1830
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Asp Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1831
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1831
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcgtgaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1832
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1832
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Val Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1833
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1833
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc attggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1834
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1834
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Leu 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1835
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1835
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa gtgtccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggggg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1836
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1836
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Val Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Gly 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1837
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1837
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gctgatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1838
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1838
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Leu Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1839
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1839
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacattaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1840
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1840
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Ile Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1841
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1841
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgctttcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1842
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1842
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Leu Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1843
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1843
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcagaattct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1844
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1844
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Asn Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1845
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1845
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtc tgttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1846
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1846
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Leu Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1847
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1847
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcgc ttgacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1848
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1848
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Leu Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1849
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1849
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaggggtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1850
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1850
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Gly Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1851
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1851
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaacaggtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1852
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1852
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Gln Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1853
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1853
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaagtaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1854
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1854
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Ser Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1855
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1855
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacctgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1856
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1856
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Leu Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1857
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1857
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggtttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1858
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1858
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1859
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1859
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgaat 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1860
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1860
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Asn Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1861
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1861
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
ctttcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1862
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1862
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Leu Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1863
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1863
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtaaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1864
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1864
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Lys Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1865
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1865
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1866
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1866
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1867
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1867
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaaccgt gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1868
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1868
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Arg Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1869
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1869
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggttga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1870
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1870
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Val Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1871
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1871
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1872
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1872
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ala Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1873
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1873
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt ttttgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1874
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1874
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Phe Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1875
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1875
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatc agtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1876
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1876
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Gln Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1877
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1877
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1878
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1878
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1879
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1879
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagtac caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1880
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Ox
 
<400> 1880
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Glu Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         


<210> 1881
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1881
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcgc tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1882
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1882
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Leu Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1883
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1883
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tgttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtgact caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggtaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatttcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1884
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1884
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Asp Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Val Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1885
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1885
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaacaagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tgttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggtaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatttcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1886
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1886
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Gln Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Val Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1887
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1887
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tgttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggtaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatttcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1888
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1888
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Val Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1889
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1889
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tgttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgctgtcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1890
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1890
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Leu Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1891
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1891
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaaccgtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tgttgatgtg gagctcttat cgtcaggatg cgtttgaggc ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggtaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgctgtcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttatcgaa taacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1892
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1892
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ala Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Val Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Leu Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Ser Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1893
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1893
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaagacgtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggtaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatttcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacggc aaacggaggt 1800
aattcgtaca gctttcaagt tccgtcggat agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1894
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1894
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Asp Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Val Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Ala Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1895
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1895
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaagacgtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggtaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatttcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1896
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1896
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Asp Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Val Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1897
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1897
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatga atggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgctgtcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1898
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1898
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Asn 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Leu Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1899
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1899
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaacaagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtgact caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggtaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1900
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1900
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Gln Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Asp Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Val Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1901
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1901
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaaccgtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggc ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcggat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggat agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1902
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1902
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ala Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1903
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1903
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaaccgtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgctgtcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacggc aaacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1904
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1904
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Leu Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Ala Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1905
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1905
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaaccgtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtc tgttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatttcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1906
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1906
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Leu Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1907
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1907
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaacaagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tgttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggtaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatttcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacggc aaacggaggt 1800
aattcgtaca gctttcaagt tccgtcggat agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1908
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1908
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Gln Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Val Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Ala Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1909
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1909
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tgttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcgc tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatga atggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatttcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1910
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1910
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Leu Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Asn 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1911
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1911
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1912
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1912
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1913
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1913
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcttct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggagcgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1914
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1914
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Ser Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1915
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1915
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcgtcaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaattc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1916
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1916
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Val Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1917
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1917
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcttct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcact ggagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat acgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgaac 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggaccgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga tgttaacgaa caacggaggt 1800
ctgtcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1918
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1918
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Leu Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Asn Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Met Leu Thr Asn Asn Gly Gly Leu Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1919
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1919
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcttct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcact ggagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatc agtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat acgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagc 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggagcgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1920
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1920
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Leu Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Gln Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Ser Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1921
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1921
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcttct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcact ggagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat acgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagc 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggagcgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1922
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1922
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Leu Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Ser Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1923
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1923
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcact ggagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat acgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagc 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggagcgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1924
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1924
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Leu Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Ser Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1925
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1925
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcact ggagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccaaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1926
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1926
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Leu Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1927
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1927
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcagaactct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggaccgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1928
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1928
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Asn Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1929
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1929
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcgtcaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcact ggagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat acgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccaaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1930
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1930
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Val Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Leu Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1931
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1931
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcgtcaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcact ggagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat acgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagc 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggactgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaattc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccaaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggaccgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1932
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1932
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Val Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Leu Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1933
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1933
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcgtcaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcttct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1934
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1934
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Val Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1935
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1935
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcttct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgaac 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggaccgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1936
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1936
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Asn Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1937
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1937
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgaccttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctgaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1938
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1938
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Glu Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1939
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1939
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaactgtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcatct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa gtctccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgaccttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat catcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctctgccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1940
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1940
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Val Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1941
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1941
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaactgtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcagcgctct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctctgccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1942
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1942
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Arg Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1943
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1943
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaactgtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcatct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa gtctccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gacgatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttggtgttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat catcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctattccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1944
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1944
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Val Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Val Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Ile Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1945
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1945
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaggggtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcatct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tattttgtat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctattccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1946
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1946
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Gly Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Cys Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Ile Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1947
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1947
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaggggtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcatct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc attcgaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acgtccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gacgatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatct gatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctattccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1948
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1948
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Gly Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Phe 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Leu Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Ile Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1949
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1949
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaactgtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcatct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acgtccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gacgatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgaccttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatct gatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctattccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1950
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1950
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Leu Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Ile Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1951
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1951
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaactgtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcagcgctct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc attcgaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat catcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctattccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1952
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1952
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Arg Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Phe 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Ile Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1953
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1953
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaactgtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcatct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc attcgaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa gtctccttat atgattcgag ctcgaactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gctgatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgaccttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat catcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctctgccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1954
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1954
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Phe 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Val Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asn Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Leu Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1955
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1955
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaactgtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcatct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acgtccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gctgatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctctgccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1956
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1956
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Leu Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1957
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1957
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttggtgttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctattccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1958
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1958
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Val Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Ile Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1959
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1959
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaacaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaactgtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcatct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat tgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa gtctccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gacgatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgaccttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat catcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggaatcc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1960
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1960
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Val Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Ile Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1961
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1961
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcgtcaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcagaactct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaattg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcccgttga cgttaacgaa caacggaggt 1800
ctgtcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1962
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1962
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Val Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Asn Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Pro 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Leu Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         


<210> 1963
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1963
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatacg aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1964
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1964
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Thr Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1965
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1965
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactggtt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1966
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1966
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gly Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1967
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1967
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactacgt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1968
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1968
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Thr Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1969
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1969
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagtt gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1970
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1970
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Leu Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1971
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1971
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacattca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1972
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1972
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Ile Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1973
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1973
atggcaaagg caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1974
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1974
Met Ala Lys Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1975
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1975
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cactttcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1976
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1976
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Phe Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1977
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1977
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgtttccg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1978
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1978
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Pro His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1979
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1979
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatgtg aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1980
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1980
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Val Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1981
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1981
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataat gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1982
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1982
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Asn Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1983
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1983
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactgatt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1984
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1984
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Asp Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1985
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1985
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attcatgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1986
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1986
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile His Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1987
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1987
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacccgca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1988
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1988
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Pro Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1989
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1989
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga catgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1990
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1990
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Met Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1991
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1991
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
atttgtgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1992
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1992
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Cys Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1993
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1993
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgacgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1994
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1994
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Thr Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1995
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1995
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaac atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1996
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1996
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln His Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1997
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1997
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatatt aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 1998
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1998
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Ile Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 1999
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 1999
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgctgcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2000
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2000
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Leu Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2001
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2001
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
gtgtggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2002
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2002
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Val Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2003
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2003
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatcat aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2004
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2004
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp His Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2005
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2005
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttaccttca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2006
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2006
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Leu Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2007
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2007
atggcatcag caccgatcgg ggtacttatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2008
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2008
Met Ala Ser Ala Pro Ile Gly Val Leu Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2009
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2009
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggactga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2010
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2010
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Thr Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2011
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2011
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacgtgca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2012
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2012
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Val Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2013
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2013
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgttgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2014
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2014
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Val Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2015
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2015
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttaccgtca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2016
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2016
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Arg Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2017
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2017
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatccgaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2018
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2018
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Pro Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2019
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2019
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt ttcgtgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2020
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2020
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Ser Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2021
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2021
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
atttctgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2022
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2022
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ser Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2023
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2023
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
ctgtcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2024
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2024
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Leu Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2025
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2025
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cagtggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2026
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2026
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Gln Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2027
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2027
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcactaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2028
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2028
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2029
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2029
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcgggggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2030
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2030
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Gly Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2031
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2031
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtaatgatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2032
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2032
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Asn Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2033
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2033
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgatcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2034
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2034
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Asp Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2035
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2035
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcatgaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2036
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2036
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Met Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2037
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2037
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2038
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2038
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2039
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2039
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaatttg gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2040
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2040
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Leu Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2041
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2041
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcgttaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2042
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2042
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Val Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2043
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2043
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcagtggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2044
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2044
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Ser Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2045
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2045
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatgat aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2046
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2046
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Asp Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2047
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2047
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggcgcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2048
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2048
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Ala Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2049
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2049
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa ccctgatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2050
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2050
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Pro 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2051
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2051
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attggtgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2052
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2052
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Gly Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2053
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2053
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacgctca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2054
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2054
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Ala Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2055
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2055
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcgcgaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2056
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2056
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ala Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2057
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2057
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaatcgt gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2058
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2058
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Arg Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2059
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2059
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2060
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2060
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2061
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2061
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcctt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2062
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2062
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Pro Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2063
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2063
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgctataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2064
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2064
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Tyr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2065
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2065
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggcatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2066
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2066
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly His Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2067
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2067
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggtgtga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2068
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2068
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Cys Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2069
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2069
atggcatcaa agccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2070
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2070
Met Ala Ser Lys Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2071
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2071
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcaagggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2072
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2072
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Lys Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2073
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2073
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa ctgtgatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2074
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2074
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Cys 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2075
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2075
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caattcgaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2076
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2076
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Ser Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2077
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2077
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatgcgaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2078
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2078
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Ala Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2079
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2079
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2080
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2080
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2081
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2081
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2082
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2082
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2083
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2083
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtactt tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacaatag cgatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2084
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2084
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asn Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2085
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2085
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2086
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2086
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2087
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2087
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatgttgta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2088
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2088
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Val Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2089
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2089
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtactt tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag cgatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2090
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2090
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2091
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2091
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacaatag cgatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2092
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2092
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asn Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2093
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2093
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgatt 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
accgatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag cgatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2094
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2094
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Ile Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Thr Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2095
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2095
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgatt 1260
ggcgagcctg gcacgagtcc gaatgttgta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtactgactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag cgatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2096
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2096
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Ile Gly Glu Pro Gly Thr Ser Pro Asn Val Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Leu Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2097
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2097
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2098
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2098
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2099
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2099
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtactt tcatcacagg aggccagcag 1380
cgcggagttc caggggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag cgatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2100
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2100
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2101
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2101
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caggggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2102
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2102
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2103
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2103
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaatgtgaa tggcctttct gtactgccac gtcaggatgg caatcaaaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacagcca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2104
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2104
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Asp Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Ser Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2105
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2105
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaat gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatagtaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaagca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2106
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2106
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Asn Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Ser Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Asp Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2107
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2107
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatcct aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaatgtgaa tggcctttct gtactgccac gtcaggatgg caatcaaaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaagca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2108
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2108
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Asp Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2109
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2109
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatagtaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2110
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2110
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Ser Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Asp Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2111
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2111
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtaat gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatgta aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaatgtgaa tggcctttct gtactgccac gtcaggatgg caatagtaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaagca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2112
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2112
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Asn Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Val Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Ser Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Asp Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2113
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2113
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aagcggtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2114
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2114
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Ala Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2115
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2115
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcgcccgt gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatgta aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatagtaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaagca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2116
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2116
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ala Arg Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Val Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Ser Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2117
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2117
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgatt 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2118
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2118
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Ile Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2119
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2119
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatagtaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgtgccc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaagca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2120
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2120
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Ser Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Cys Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Asp Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2121
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2121
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaat gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatcct aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaatgtgaa tggcctttct gtactgccac gtcaggatgg caatagtaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2122
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2122
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Asn Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Ser Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2123
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2123
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtcgt gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcaaaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacagcca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2124
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2124
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Arg Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Asp Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Ser Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2125
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2125
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattcgt gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaatgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaagca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggcg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2126
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2126
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Arg Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Asp Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2127
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2127
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2128
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2128
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2129
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2129
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacaatag caatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2130
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2130
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asn Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2131
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2131
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caggggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2132
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2132
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2133
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2133
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgatt 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtactt tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2134
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2134
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Ile Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2135
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2135
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtcgt gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatagtaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaagca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2136
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2136
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Arg Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Ser Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Asp Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2137
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2137
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc caggggaaga tagcacaccc gtatttactc cagagatcta ctttcccgaa 1440
accgatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2138
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2138
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Phe Pro Glu 
465                 470                 475                 480 
Thr Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2139
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2139
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatcct aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2140
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2140
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Asp Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2141
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2141
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatgta aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaatgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacagcca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2142
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2142
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Val Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Asp Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Ser Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2143
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2143
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgatt 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caggggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2144
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2144
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Ile Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2145
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2145
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatcct aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaagca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2146
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2146
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Asp Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2147
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2147
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtcgt gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcaaaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaagca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2148
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2148
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Arg Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2149
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2149
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataat gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatact aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaatgtgaa tggcctttct gtactgccac gtcaggatgg caatagtaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgtgccc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2150
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2150
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Asn Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Thr Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Ser Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Cys Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2151
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2151
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcgccaat gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatgaaaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgtgccc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2152
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2152
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ala Asn Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Glu Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Cys Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2153
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2153
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc caggggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2154
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2154
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2155
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2155
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgatt 1260
ggcgagcctg gcacgagtcc gaatacgata tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caggggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag cgatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2156
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2156
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Ile Gly Glu Pro Gly Thr Ser Pro Asn Thr Ile Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2157
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2157
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2158
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2158
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2159
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2159
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgatt 1260
ggcgagcctg gcacgagtcc gaatgttgta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc caggggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2160
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2160
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Ile Gly Glu Pro Gly Thr Ser Pro Asn Val Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2161
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2161
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2162
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2162
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2163
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2163
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggggtcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2164
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2164
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2165
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2165
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaatcgg gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2166
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2166
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Arg Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2167
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2167
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatgta aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcaaaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacatcca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2168
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2168
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Val Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Ile Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2169
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2169
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcactaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2170
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2170
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Thr Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2171
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2171
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcgcgaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2172
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2172
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ala Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2173
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2173
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactgatt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2174
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2174
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Asp Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Asp Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2175
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2175
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatgttgta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc caggggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2176
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2176
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Val Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2177
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2177
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtcgt gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaatgtgaa tggcctttct gtactgccac gtcaggatgg caatcaaaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatga tgattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaagca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2178
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2178
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Arg Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Asp Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2179
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2179
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgctcgaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2180
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2180
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2181
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2181
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtactt tcatcacagg aggccagcag 1380
cgcggagttc caggggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2182
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2182
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2183
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2183
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg ggggtcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttactcgca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2184
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2184
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Ser Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2185
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2185
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacagcca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2186
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2186
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Ser Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2187
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2187
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactctgagt 840
gatgggcgcg tatttacgat tggcggcagt ttttccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgatt 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtactt tcatcacagg aggccagcag 1380
cgcggagttc caggggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2188
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2188
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Leu Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Ile Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2189
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2189
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatgttgta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caggggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2190
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2190
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Val Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2191
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2191
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtactt tcatcacagg aggccagcag 1380
cgcggagttc caggggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacaatag cgatgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2192
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2192
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Gly Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asn Ser Asp Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2193
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2193
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggggtcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2194
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2194
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2195
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2195
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtcgt gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatagtaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaagca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2196
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2196
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Arg Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Ser Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2197
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2197
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacatcca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2198
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2198
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Ile Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2199
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2199
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaagca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgccgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctatcccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2200
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2200
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Ile Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2201
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2201
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgatgcc gggcttgggg 480
gcctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt ttctccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat caaatcgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacct tcatcacagg aggccagcag 1380
cgcggagttc caacggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacgcgca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctctgccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2202
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2202
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Met Pro Gly Leu Gly 
145                 150                 155                 160 
Ala Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Phe Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asn Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Thr Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Ala Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         


<210> 2203
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2203
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtact gggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2204
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2204
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Leu Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2205
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2205
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg gggataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2206
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2206
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Gly Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2207
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2207
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttaag gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2208
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2208
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Arg Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2209
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2209
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggac tggtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2210
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2210
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Leu Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2211
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2211
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agcttcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2212
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2212
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Ala Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2213
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2213
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattgggc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2214
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2214
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Trp Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2215
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2215
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagcagcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2216
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2216
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Gln Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2217
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2217
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccttg 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2218
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2218
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Leu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2219
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2219
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacac tggcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2220
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2220
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Leu Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2221
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2221
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa cacgggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2222
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2222
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Thr Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2223
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2223
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ggggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2224
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2224
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Gly Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2225
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2225
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2226
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2226
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2227
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2227
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagat gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2228
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2228
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Met Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2229
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2229
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagct ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2230
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2230
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Leu Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2231
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2231
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2232
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2232
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2233
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2233
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2234
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2234
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Glu Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2235
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2235
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggagat 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2236
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2236
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Asp Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2237
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2237
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2238
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2238
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2239
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2239
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg ccttcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2240
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2240
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Leu Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2241
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2241
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtctcggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2242
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2242
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Ser Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2243
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2243
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg ggcatgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2244
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2244
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly His Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2245
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2245
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagca ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2246
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2246
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu His Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2247
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2247
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactcag 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2248
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2248
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Gln Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2249
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2249
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt ttcttaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2250
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2250
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Leu Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2251
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2251
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gggggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2252
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2252
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Arg Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2253
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2253
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagca gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2254
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2254
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gln Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2255
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2255
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggcggaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2256
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2256
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Arg Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2257
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2257
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagcca gtgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2258
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2258
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Gln Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2259
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2259
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtttg 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2260
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2260
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Leu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2261
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2261
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaga tggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2262
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2262
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asp Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2263
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2263
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagtg gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2264
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2264
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Trp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2265
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2265
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg tcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2266
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2266
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ser Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2267
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2267
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcgtgagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2268
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2268
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2269
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2269
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaataaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2270
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2270
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Asn Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2271
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2271
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2272
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2272
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2273
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2273
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactcgt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2274
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2274
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Arg Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2275
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2275
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggca agcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2276
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2276
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Lys Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2277
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2277
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttaaa tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2278
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2278
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Asn Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2279
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2279
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2280
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2280
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2281
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2281
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagca ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2282
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2282
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu His Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2283
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2283
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggagaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2284
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2284
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Arg Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2285
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2285
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacgt tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2286
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2286
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2287
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2287
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggctgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacgt tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2288
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2288
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2289
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2289
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggctgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat agg                              1953

 
<210> 2290
<211> 651
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2290
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His Arg                     
                645                 650                         

 
<210> 2291
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2291
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggctgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2292
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2292
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2293
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2293
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgaacctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2294
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2294
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2295
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2295
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacgt tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2296
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2296
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2297
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2297
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtactgactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2298
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2298
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Leu Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2299
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2299
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2300
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2300
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2301
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2301
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacgt tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2302
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2302
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2303
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2303
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2304
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2304
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2305
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2305
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2306
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2306
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2307
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2307
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggctgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacgt tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2308
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2308
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2309
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2309
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2310
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2310
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2311
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2311
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2312
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2312
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2313
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2313
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gtttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2314
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2314
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2315
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2315
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtatttgaca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2316
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2316
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Leu Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2317
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2317
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacgt tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2318
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2318
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2319
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2319
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagct gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2320
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2320
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Leu Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2321
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2321
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc atctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2322
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2322
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2323
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2323
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgagg ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2324
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2324
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Val 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2325
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2325
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc atctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2326
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2326
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2327
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2327
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc atctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacgt tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2328
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2328
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2329
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2329
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagat gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2330
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2330
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Met Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2331
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2331
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc atctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggctgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtacgt tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2332
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2332
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Thr Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2333
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2333
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc atctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggctgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2334
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2334
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2335
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2335
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactgggt atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2336
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2336
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gly Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2337
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2337
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgttat 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2338
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2338
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Tyr Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2339
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2339
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca cgtgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatg accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttatactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgca atcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtactgactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2340
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2340
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Thr Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Met Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Gln Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Leu Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2341
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2341
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt ttcggaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2342
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2342
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Arg Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2343
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2343
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaataaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2344
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2344
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Asn Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2345
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2345
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca cgtgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgca atcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggtgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg ggattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt tggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2346
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2346
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Thr Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Gln Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2347
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2347
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtacgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2348
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2348
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Thr Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2349
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2349
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc atctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2350
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2350
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2351
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2351
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcggc gtcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2352
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2352
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ala Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2353
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2353
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagtg gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2354
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2354
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Trp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2355
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2355
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc atctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtactgactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2356
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2356
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Leu Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2357
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2357
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atccatttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2358
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2358
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile His 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2359
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2359
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc atctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggctgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2360
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2360
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2361
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2361
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttacg gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2362
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2362
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Arg Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2363
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2363
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcagtaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc atctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggctgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtactgactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2364
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2364
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ser Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Leu Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2365
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2365
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2366
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2366
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2367
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2367
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc aggggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2368
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2368
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Gln Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2369
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2369
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttagg gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2370
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2370
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Gly Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2371
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2371
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggag cggtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2372
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2372
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ala Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2373
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2373
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttata tttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2374
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2374
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Tyr Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2375
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2375
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagagc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2376
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2376
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Glu Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2377
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2377
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgactc ttcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2378
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2378
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Ser Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2379
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2379
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2380
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2380
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2381
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2381
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc atctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggatgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2382
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2382
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Met Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2383
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2383
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttac gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2384
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2384
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Thr Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2385
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2385
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatt 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2386
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2386
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Ile 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2387
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2387
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggggg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2388
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2388
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Gly 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2389
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2389
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca aatgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgga atcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt tggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2390
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2390
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Lys Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Glu Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2391
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2391
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagggg 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2392
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2392
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gly Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2393
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2393
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atggggggcc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc atctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggctgct gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2394
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2394
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gly Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2395
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2395
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccgtg accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgtc gtcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
aatgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg ggattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt tggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2396
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2396
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Val Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Asn Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2397
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2397
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcaataag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcc gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcggc gtcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtactgactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg ggattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt tggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2398
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2398
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Asn Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Pro Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ala Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Leu Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         


<210> 2399
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2399
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagct gtctcctggc 600
ggtattacac tgacgagcga ttgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2400
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2400
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Leu Ser Pro Gly Gly Ile Thr Leu Thr Ser Asp Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2401
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2401
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagat gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctggttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2402
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2402
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Met Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Val Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2403
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2403
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2404
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2404
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2405
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2405
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaaccc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagcag ctgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2406
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2406
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2407
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2407
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtcc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagcag ctgggaccct agcactggaa ttgtatccga tcgcattagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2408
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2408
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Ile Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2409
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2409
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtcc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagat gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2410
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2410
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Met Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2411
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2411
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaaccc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagat gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg tcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2412
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2412
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Met Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ser Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2413
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2413
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggag ccgtatccga tcgcaccagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaataaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtatctgaca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2414
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2414
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ala Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Asn Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Leu Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2415
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2415
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagat gtctcctggc 600
ggtattacac tgacgagcag ctgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2416
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2416
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Met Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2417
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2417
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaaccc aaaacgtgaa aggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggag cggtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2418
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2418
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Lys Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ala Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2419
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2419
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtcc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2420
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2420
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2421
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2421
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaataaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtacgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2422
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2422
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Asn Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Thr Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2423
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2423
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2424
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2424
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2425
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2425
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagat gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2426
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2426
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Met Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2427
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2427
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagca ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggag ccgtatccga tcgcaccagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2428
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2428
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu His Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ala Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2429
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2429
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaaccc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2430
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2430
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2431
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2431
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2432
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2432
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2433
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2433
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagct gtctcctggc 600
ggtattacac tgacgagcag ctgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2434
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2434
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Leu Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2435
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2435
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc aagggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcaccagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2436
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2436
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Gln Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2437
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2437
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaaccc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagcag ctgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2438
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2438
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2439
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2439
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaaccc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2440
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2440
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2441
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2441
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagat gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg tcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2442
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2442
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Met Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ser Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2443
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2443
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaaccc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggag cggtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg tcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2444
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2444
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ala Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ser Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2445
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2445
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtcc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggag cggtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2446
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2446
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ala Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2447
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2447
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagct gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg tcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2448
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2448
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Leu Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ser Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2449
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2449
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggag cggtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2450
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2450
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ala Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2451
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2451
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagat gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggag cggtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2452
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2452
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Met Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ala Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2453
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2453
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactggct atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaataaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2454
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2454
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gly Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Asn Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2455
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2455
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaaccc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagct gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctggttggg 1020
aggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2456
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2456
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Leu Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Val Gly Arg Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2457
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2457
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtcc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2458
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2458
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2459
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2459
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtcc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagct gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2460
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2460
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Leu Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2461
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2461
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggcgtaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcaccagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2462
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2462
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Arg Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2463
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2463
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaaccc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2464
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2464
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2465
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2465
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagat gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggag cggtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg tcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2466
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2466
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Met Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ala Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ser Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2467
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2467
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2468
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2468
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2469
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2469
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggag cggtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2470
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2470
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ala Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2471
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2471
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaaccc aaaacgtgaa aggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagcag ctgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg tcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2472
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2472
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Lys Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ser Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2473
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2473
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaaccc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagct gtctcctggc 600
ggtattacac tgacgagcga ttgggaccct agcactggag cggtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2474
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2474
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Leu Ser Pro Gly Gly Ile Thr Leu Thr Ser Asp Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ala Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2475
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2475
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc aagggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcaccagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2476
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2476
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Gln Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2477
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2477
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc aagggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagca gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcaccagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaataaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttacg cttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2478
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2478
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Gln Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gln Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Asn Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Arg Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2479
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2479
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtcc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg tcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2480
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2480
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ser Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2481
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2481
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaaccc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgtccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg tcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2482
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2482
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ser Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2483
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2483
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcaccagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2484
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2484
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2485
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2485
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggcgtaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtatctgaca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2486
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2486
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Arg Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Leu Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2487
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2487
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaaccc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2488
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2488
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2489
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2489
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ttctcctggc 600
ggtattacac tgacgagcag ctgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2490
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2490
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2491
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2491
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaaccc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagcga ttgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2492
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2492
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Asp Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2493
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2493
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactggct atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcaccagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtatctgaca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2494
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2494
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gly Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Leu Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2495
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2495
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagcga ttgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg tcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2496
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2496
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Asp Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ser Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2497
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2497
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg tcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2498
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2498
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ser Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2499
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2499
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagat gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctggttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg tcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2500
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2500
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Met Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Val Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ser Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2501
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2501
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg tcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2502
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2502
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ser Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2503
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2503
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg tcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2504
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2504
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ser Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2505
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2505
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacaaccc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagag ctctcctggc 600
ggtattacac tgacgagcga ttgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg tcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2506
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2506
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Ser Ser Pro Gly Gly Ile Thr Leu Thr Ser Asp Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ser Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2507
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2507
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagcga ttgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg tcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2508
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2508
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Asp Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ser Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2509
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2509
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgaggg ttctcctggc 600
ggtattacac tgacgagcga ttgggaccct agcactggag cggtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc atatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgttgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2510
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2510
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Gly Ser Pro Gly Gly Ile Thr Leu Thr Ser Asp Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ala Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Ile Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2511
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2511
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc aagggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc caaccgccgc acaccatcac gatcgatatg 180
aaaacaacgc aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcaccagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtatctgaca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2512
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2512
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Gln Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Gln Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Thr Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Leu Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2513
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2513
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagatgcgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagct gtctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggag cggtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcggtgt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gcggcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2514
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2514
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Met Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Leu Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ala Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Gly Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         


<210> 2515
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2515
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttaggga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2516
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2516
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Arg Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2517
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2517
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaacg gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2518
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2518
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Arg Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2519
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2519
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatcg ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2520
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2520
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Arg Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2521
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2521
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cacgggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2522
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2522
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Arg Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2523
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2523
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgcat cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acgttccata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcctgtgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2524
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2524
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu His Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2525
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2525
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctaccata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggcgttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcctgtgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacactg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2526
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2526
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Tyr His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2527
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2527
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtcagga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctaccata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggcgttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttcgatctcg 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcctgtgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2528
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2528
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Gln Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Tyr His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2529
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2529
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcactctg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2530
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2530
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Ser Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2531
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2531
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaaa gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2532
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2532
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Lys Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2533
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2533
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtcagga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca aaattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctaccata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcgccgttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcctgtgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2534
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2534
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Gln Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asn Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Tyr His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Ala Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2535
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2535
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tataggggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2536
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2536
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Arg Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2537
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2537
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacgggg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2538
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2538
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Gly Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2539
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2539
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcgccgttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacgctg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2540
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2540
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Ala Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Ala Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2541
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2541
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattataa ggattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2542
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2542
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Lys Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2543
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2543
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttgtatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2544
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2544
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Cys Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2545
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2545
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttcagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2546
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2546
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Gln Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2547
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2547
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaacg gggttggtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2548
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2548
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Arg Gly Trp Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2549
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2549
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtagtga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctaccata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcctgtgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2550
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2550
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Ser Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Tyr His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2551
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2551
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gttccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcgtat cgtcaggatg cgtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctaccata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcgccgttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcctatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcatgtgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2552
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2552
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Tyr His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Ala Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Met Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2553
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2553
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg ggtttgagga ctctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa ttgtatccga tcgcactagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgcat cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtagttatca tagcatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcctgtgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacactg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2554
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2554
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Gly Phe Glu Asp Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Thr Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu His Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ser Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         


<210> 2555
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2555
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca acagtcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2556
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2556
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Gln Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2557
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2557
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccctg 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2558
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2558
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Leu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2559
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2559
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaaat 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2560
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2560
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Asn Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2561
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2561
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2562
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2562
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2563
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2563
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc tgtgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2564
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2564
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Leu Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2565
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2565
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc gctgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgtgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccaa 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2566
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2566
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Arg Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2567
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2567
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgggttatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2568
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2568
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2569
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2569
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaatgtg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2570
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2570
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Met 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2571
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2571
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaagttg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2572
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2572
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Ser 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2573
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2573
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2574
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2574
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2575
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2575
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacaagt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2576
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2576
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Ser Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2577
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2577
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tatggtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2578
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2578
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Met Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2579
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2579
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccctgacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2580
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2580
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Leu Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2581
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2581
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2582
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2582
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2583
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2583
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgattg taacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2584
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2584
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Cys Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2585
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2585
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttgtgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2586
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2586
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Cys Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2587
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2587
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtggtgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2588
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2588
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Gly Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2589
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2589
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgtggatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2590
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2590
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2591
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2591
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggattgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2592
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2592
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Leu Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2593
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2593
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggagttcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2594
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2594
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Val Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2595
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2595
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtcctaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2596
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2596
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Pro Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2597
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2597
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggctaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2598
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2598
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Ala Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2599
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2599
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatt 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2600
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2600
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Ile 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2601
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2601
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttgtaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2602
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2602
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Cys Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2603
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2603
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataagga cacgttttgg 120
cacactcaat atggtgagaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtggcgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccctgacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2604
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2604
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Glu Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Gly Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Leu Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2605
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2605
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtgaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttgcaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaaat 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2606
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2606
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Cys Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Asn Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2607
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2607
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgagaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtggcgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccggggtatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2608
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2608
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Glu Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Gly Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2609
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2609
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggagtgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcggggag 1680
atcaccattt ggactgacat gtcaatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2610
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2610
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Val Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Glu 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2611
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2611
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgagaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtggcgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccggggtatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2612
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2612
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Glu Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Gly Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2613
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2613
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtgaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccctg 1440
caagatactt tttgcaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccggggtatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcggggag 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaaat 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2614
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2614
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Leu 
465                 470                 475                 480 
Gln Asp Thr Phe Cys Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Glu 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Asn Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2615
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2615
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataagga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggagtgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2616
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2616
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Val Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2617
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2617
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataagga cacgttttgg 120
cacactcaat atggtgagaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttgcaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccggggtatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2618
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2618
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Glu Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Cys Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2619
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2619
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtgaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggagtgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccggggtatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccctgacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaaat 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2620
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2620
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Val Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Leu Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Asn Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2621
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2621
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataagga cacgttttgg 120
cacactcaat atggtgagaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggagtgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccctgacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaaat 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2622
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2622
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Glu Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Val Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Leu Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Asn Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2623
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2623
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtggcgatg ggtcgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttgcaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccggggtatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccctgacc tcaacccagt cagtcgtggt cggcggggag 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2624
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2624
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Gly Asp Gly Ser Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Cys Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Leu Thr Ser Thr Gln Ser Val Val Val Gly Gly Glu 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2625
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2625
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgagaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggagtgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccggggtatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccctgacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2626
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2626
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Glu Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Val Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Leu Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2627
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2627
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggagtgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccctg 1440
caagatactt tttgcaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2628
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2628
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Val Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Leu 
465                 470                 475                 480 
Gln Asp Thr Phe Cys Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2629
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2629
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtgaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtggcgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttgcaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2630
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2630
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Gly Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Cys Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2631
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2631
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtgaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggagtgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttgcaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccggggtatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaaat 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2632
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2632
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Val Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Cys Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Asn Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2633
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2633
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccggggtatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2634
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2634
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2635
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2635
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2636
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2636
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2637
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2637
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataagga cacgttttgg 120
cacactcaat atggtgagaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagcgatg ggtcgaattg gggagtgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccggggtatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2638
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2638
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Glu Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Ser Asn 
                85                  90                  95      
Trp Gly Val Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2639
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2639
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataagga cacgttttgg 120
cacactcaat atggtgtgaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccctg 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccggggtatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccctgacc tcaacccagt cagtcgtggt cggcggggag 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2640
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2640
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Leu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Leu Thr Ser Thr Gln Ser Val Val Val Gly Gly Glu 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2641
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2641
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagcgatg gggtgatgtg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2642
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2642
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Met 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2643
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2643
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtgaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtggcgatg ggtcgaattg gggagtgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcggggag 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2644
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2644
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Gly Asp Gly Ser Asn 
                85                  90                  95      
Trp Gly Val Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Glu 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2645
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2645
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataagga cacgttttgg 120
cacactcaat atggtgtgaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagcgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccctg 1440
caagatactt tttgcaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2646
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2646
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Leu 
465                 470                 475                 480 
Gln Asp Thr Phe Cys Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2647
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2647
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagcgatg gggtgatgtg gggagtgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccggggtatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccctgacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2648
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2648
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Met 
                85                  90                  95      
Trp Gly Val Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Leu Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2649
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2649
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccctgacc tcaacccagt cagtcgtggt cggcggggag 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2650
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2650
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Leu Thr Ser Thr Gln Ser Val Val Val Gly Gly Glu 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2651
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2651
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagcgatg ggtcgaattg gggagtgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttgcaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2652
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2652
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Ser Asn 
                85                  90                  95      
Trp Gly Val Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Cys Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2653
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2653
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccctgacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaaat 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2654
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2654
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Leu Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Asn Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2655
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2655
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagcgatg ggtcgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccggggtatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2656
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2656
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Ser Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2657
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2657
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgcattaag gcaattgacg gtaataagga cacgttttgg 120
cacactcaat atggtgtgaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttgcaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaaat 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2658
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2658
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Cys Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Asn Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2659
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2659
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtgaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccggggtatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2660
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2660
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2661
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2661
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgttgatg gggtaaattg gggactgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tatggtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agactcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatt 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2662
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2662
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Leu Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Met Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Ile 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2663
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2663
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtccgaa tggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgttgatg gggtaaattg gggaagtcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgc 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatt 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2664
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2664
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Pro Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Ile 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2665
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2665
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc tgtgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgttgatg gggtaagttg gggaagtcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacaagc 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgtgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagacatggg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agactcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2666
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2666
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Leu Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Val Ser 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Ser Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Met Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2667
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2667
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc gctgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca acaatcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2668
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2668
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Arg Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Gln Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2669
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2669
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc gctgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagacatggg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agactcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatt 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2670
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2670
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Arg Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Met Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Ile 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2671
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2671
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaagttg gggactgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgc 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2672
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2672
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Ser 
                85                  90                  95      
Trp Gly Leu Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2673
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2673
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc tgtgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgttgatg gggtaagttg gggactgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgtgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2674
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2674
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Leu Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Val Ser 
                85                  90                  95      
Trp Gly Leu Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2675
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2675
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc gctgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgttgatg gggtaaattg gggactgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacaagc 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgtgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgattg caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2676
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2676
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Arg Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Leu Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Ser Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Cys Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2677
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2677
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc gctgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttgcgatg gggtaagttg gggactgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca acgttcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2678
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2678
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Arg Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Cys Asp Gly Val Ser 
                85                  90                  95      
Trp Gly Leu Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Arg Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2679
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2679
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggcgcaactg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacactg 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaacgtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaatggcgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2680
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2680
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Arg Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Leu Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Arg Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Gly Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2681
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2681
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc tgtgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgttgatg gggtaagttg gggactgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacaagc 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agactcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgattg caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2682
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2682
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Leu Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Val Ser 
                85                  90                  95      
Trp Gly Leu Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Ser Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Cys Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2683
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2683
atggcatcag caccgatcgg ggtagccatc ccgcgcaacg cttgggccgt tacatgcgat 60
tccgcccagg tagggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg cattcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacactg 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cgtagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg cggataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tcggggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgag 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2684
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2684
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Ala Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Val Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Ile Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Leu Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Val Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2685
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2685
atggcatcag caccgatcgg ggtagccatc ccgcgcaacg cttgggccgt tacatgcgat 60
tccgcccagg tagggaatga atgcattaag gcaattgacg gtaatcctga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtcggctg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg cggataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tcggggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg ggacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2686
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2686
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Ala Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Val Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Gly 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2687
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2687
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccagg tagggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaacgtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tcggggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2688
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2688
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Val Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Arg Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2689
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2689
atggcatcag caccgatcgg ggtagccatc ccgcgcaacg cttgggccgt tacatgcgat 60
tccgcccagg tagggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtcggctg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cgtagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg cggataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaatggcgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2690
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2690
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Ala Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Val Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Gly 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Val Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Gly Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2691
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2691
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacactg 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgacct ttgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tcggggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttccccgc 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2692
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2692
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Leu Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Phe Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Arg 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Met 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2693
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2693
atggcatcag caccgatcgg ggtagccatc ccgcgcaacg cttgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg cattcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacactg 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cgtagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tcggggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgag 1440
caagatactt tttacaaaca aaccccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaatggcgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2694
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2694
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Ala Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Ile Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Leu Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Val Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Thr Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Met 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Gly Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2695
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2695
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccagg tagggaatga atgcattaag gcaattgacg gtaatcctga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggcgcggctg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg cggataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg ggacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2696
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2696
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Val Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Arg Gly 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2697
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2697
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccagg tagggaatga atgcattaag gcaattgacg gtaatcctga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacactg 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaacgtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg cggataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tcggggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttccccgc 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2698
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2698
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Val Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Leu Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Arg Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Arg 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Met 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2699
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2699
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaatcctga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cgtagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaacgtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tcggggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgag 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2700
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2700
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Val Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Arg Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2701
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2701
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtcggctg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgag 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaatagcgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2702
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2702
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Gly 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2703
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2703
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtcctgtg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cgtagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg cggataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaatggcgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2704
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2704
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Leu 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Val Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Met 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Gly Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2705
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2705
atggcatcag caccgatcgg ggtagccatc ccgcgcaacg cttgggccgt tacatgcgat 60
tccgcccagg tagggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cgtagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg cggataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2706
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2706
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Ala Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Val Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Val Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Met 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2707
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2707
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccagg tagggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaacgtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgacct ttgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tcggggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttccccgc 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2708
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2708
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Val Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Arg Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Phe Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Arg 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2709
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2709
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaacgtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgacct ttgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tcggggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaatagcgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2710
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2710
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Arg Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Phe Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2711
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2711
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaacgtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgacct ttgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgag 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2712
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2712
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Arg Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Phe Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Met 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2713
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2713
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgacct ttgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2714
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2714
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Phe Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Met 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2715
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2715
atggcatcag caccgatcgg ggtagccatc ccgcgcaacg cttgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cgtagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaacgtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg cggataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgag 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2716
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2716
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Ala Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Val Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Arg Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Met 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2717
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2717
atggcatcag caccgatcgg ggtagccatc ccgcgcaacg cttgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtcaactg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacactg 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagtgga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttccccgc 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaatggcgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2718
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2718
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Ala Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Leu Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Arg 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Gly Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2719
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2719
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttccccgc 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2720
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2720
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Arg 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2721
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2721
atggcatcag caccgatcgg ggtagccatc ccgcgcaacg cttgggccgt tacatgcgat 60
tccgcccagg tagggaatga atgcattaag gcaattgacg gtaatcctga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaacgtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg cggataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tcggggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctt ggacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgag 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaatagcgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2722
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2722
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Ala Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Val Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Arg Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Trp Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Met 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2723
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2723
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaatcctga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cgtagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaacgtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgacct ttgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tcggggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg ggacgagtcc gaatacggta tttgcgggta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgag 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaatggcgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2724
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2724
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Pro Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Val Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Arg Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Phe Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Gly Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Gly Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2725
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2725
atggcatcag caccgatcgg ggtagccatc ccgcgcaacg cttgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg ggcgcaactg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacactg 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaacgtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg cggataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttccccgc 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2726
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2726
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Ala Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Arg Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Leu Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Arg Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Arg 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Met 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2727
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2727
atggcatcag caccgatcgg ggtagccatc ccgcgcaacg cttgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtcaactg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cgtagactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg cggataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgag 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2728
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2728
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Ala Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Val Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2729
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2729
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagcgatg gggtcaactg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca actgtcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgattg gaacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttacaaaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2730
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2730
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Leu Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Trp Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Gln Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2731
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2731
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgccgcga gtgggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttgcgatg ggttcggctg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2732
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2732
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Ala Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Cys Asp Gly Phe Gly 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2733
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2733
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgccgcga gtgggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgattg gaacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttacaaaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2734
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2734
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Ala Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Trp Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Gln Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2735
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2735
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttgcgatg ggttcaactg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gcacacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgattc gaacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttacaaaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2736
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2736
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Cys Asp Gly Phe Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro His Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Gln Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2737
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2737
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaacacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgattg gaacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccgc 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2738
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2738
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Trp Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Arg 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2739
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2739
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca actgtcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttacaaaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2740
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2740
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Leu Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Gln Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2741
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2741
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tggcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca actgtcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaactaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2742
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2742
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Gly Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Leu Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2743
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2743
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgccgcga gtgggaatga atgcattaag gcaattgacg gtaataagga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tggcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaacacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgattg gaacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaactaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2744
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2744
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Ala Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Gly Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Trp Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2745
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2745
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttagttaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2746
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2746
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Val Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2747
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2747
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttgcgatg gggtcggctg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca actgtcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gcacacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgattc gaacgggcgt 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttagttaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2748
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2748
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Cys Asp Gly Val Gly 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Leu Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro His Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Arg Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Val Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2749
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2749
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgccgcga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca actgtcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttagttaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2750
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2750
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Ala Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Leu Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Val Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2751
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2751
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgccgcga gtgggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca actgtcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gcacacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2752
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2752
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Ala Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Leu Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro His Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2753
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2753
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgccgcga gtgggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttgcgatg ggttcaactg gggattccct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca actgtcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttagttaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2754
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2754
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Ala Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Cys Asp Gly Phe Asn 
                85                  90                  95      
Trp Gly Phe Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Leu Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Val Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2755
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2755
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagcgatg ggttcaactg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2756
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2756
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Phe Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2757
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2757
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca actgtcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaacacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgattc gaacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2758
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2758
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Leu Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2759
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2759
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataagga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagcgatg gggtgatgtg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcggggag 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2760
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2760
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Met 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Glu 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2761
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2761
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaaaggga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2762
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2762
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Arg Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2763
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2763
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttccccgg 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2764
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2764
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Arg 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2765
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2765
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagg tggggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2766
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2766
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Val Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2767
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2767
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacactt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2768
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2768
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Leu Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2769
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2769
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2770
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2770
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Met 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2771
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2771
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg cattcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2772
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2772
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Ile Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2773
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2773
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtggggatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2774
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2774
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Gly Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2775
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2775
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtagggtg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2776
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2776
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Gly 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2777
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2777
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cgtggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2778
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2778
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Val Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2779
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2779
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
ccggggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2780
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2780
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Pro Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2781
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2781
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaatggtgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2782
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2782
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Gly Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2783
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2783
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataagga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttgcaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2784
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2784
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Cys Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2785
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2785
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtcgcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2786
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2786
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2787
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2787
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagt cggggaatga atgcattaag gcaattgacg gtaataagga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccggggtatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccctgacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2788
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2788
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Leu Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2789
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2789
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataagga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccggggtatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2790
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2790
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Gly Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2791
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2791
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat caccctgacc tcaacccagt cagtcgtggt cggcggggag 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2792
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2792
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Leu Thr Ser Thr Gln Ser Val Val Val Gly Gly Glu 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2793
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2793
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttgcaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgcacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2794
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2794
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Cys Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2795
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2795
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagcgatg gggtgaattg gggagtgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgtggcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttgcaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaaat 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2796
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2796
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Val Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Trp Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Cys Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Asn Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2797
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2797
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtggcgatg gggtgaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgg ctgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2798
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2798
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Gly Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Ala Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2799
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2799
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgacct ttgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2800
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2800
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Phe Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2801
<211> 1953
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2801
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaatgtg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat tag                              1953

 
<210> 2802
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2802
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Met 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2803
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2803
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc gctgggccgt tacatgcgat 60
tccgcccagc cggggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggactgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tatggtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca acaatcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgattg caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatt 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2804
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2804
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Arg Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Pro Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Leu Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Met Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Gln Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Cys Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Ile 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2805
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2805
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc gctgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgattg caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2806
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2806
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Arg Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Cys Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2807
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2807
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc gctgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtccgaa tggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagcgatg gggtaagttg gggactgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agactcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatt 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2808
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2808
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Arg Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Pro Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Ser 
                85                  90                  95      
Trp Gly Leu Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Ile 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2809
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2809
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc gctgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgttgatg gggtaaattg gggactgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tatggtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca acaatcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2810
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2810
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Arg Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Leu Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Met Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Gln Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2811
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2811
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc tgtgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagacatggg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgattg caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2812
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2812
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Leu Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Met Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Cys Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2813
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2813
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc tgtgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgttgatg gggtaaattg gggactgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacaagc 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tatggtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca acgttcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2814
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2814
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Leu Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Leu Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Ser Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Met Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Arg Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2815
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2815
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc gctgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttgcgatg gggtaagttg gggaagtcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgc 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagacatggg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agactcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2816
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2816
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Arg Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Cys Asp Gly Val Ser 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Met Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2817
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2817
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc tgtgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgtgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagacatggg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2818
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2818
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Leu Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Met Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2819
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2819
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgttgatg gggtaaattg gggaagtcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tatggtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2820
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2820
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Met Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2821
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2821
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc gctgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgttgatg gggtaagttg gggactgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagacatggg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatt 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2822
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2822
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Arg Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Val Ser 
                85                  90                  95      
Trp Gly Leu Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Met Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Ile 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2823
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2823
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc tgtgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttgcgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tatggtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca acaatcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2824
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2824
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Leu Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Cys Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Met Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Gln Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2825
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2825
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgccgcga gtgggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagcgatg gggtcggctg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca actgtcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaacacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgattc gaacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttagttaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccgc 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2826
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2826
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Ala Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Gly 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Leu Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Val Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Arg 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2827
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2827
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc gctgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtccgcc aggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagacatggg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agactcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2828
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2828
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Arg Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Pro Pro Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Met Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2829
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2829
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca actgtcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaacacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2830
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2830
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Leu Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2831
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2831
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgttgatg gggtaagttg gggaagtcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2832
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2832
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Val Ser 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2833
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2833
atggcatcag caccgatcgg ggtagccatc ccgcgcaacc tgtgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtcaa tggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgtgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagacatggg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatt 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2834
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2834
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Leu Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Met Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Ile 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2835
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2835
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag cagcgactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaacgtga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttccccgc 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggatg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2836
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2836
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Arg Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Arg 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Met 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2837
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2837
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacaagc 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagacatggg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2838
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2838
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Ser Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Met Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2839
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2839
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgccgcga gtgggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgattg gaacgggcgt 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccgc 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2840
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2840
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Ala Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Trp Asn Gly Arg Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Arg 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2841
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2841
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctt ggacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2842
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2842
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Trp Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2843
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2843
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca attgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtgttgatg gggtaaattg gggactgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacaagc 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2844
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2844
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Val Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Leu Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Ser Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2845
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2845
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agtagcgatg ggttcggctg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaacacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2846
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2846
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Phe Gly 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2847
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2847
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgccgcga gtgggaatga atgcattaag gcaattgacg gtaatctgga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaacgaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2848
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2848
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Ala Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Leu Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2849
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2849
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggattgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaactaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccgc 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2850
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2850
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Leu Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Arg 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2851
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2851
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataagga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tggcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaacacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgattg gaacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttagttaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2852
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2852
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Gly Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Trp Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Val Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2853
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2853
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaacacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttaactaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccgc 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2854
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2854
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Thr Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Arg 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2855
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2855
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgccgcga gtgggaatga atgcattaag gcaattgacg gtaataagga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tggcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttacaaaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccgc 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2856
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2856
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Ala Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Gly Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Gln Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Arg 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2857
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2857
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tcgcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca actgtcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttacaaaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2858
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2858
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Arg Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Leu Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Gln Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

 
<210> 2859
<211> 1950
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2859
atggcatcag caccgatcgg ggtagccatc ccgcgcaaca actgggccgt tacatgcgat 60
tccgcccaga gtgggaatga atgcattaag gcaattgacg gtaataaaga cacgttttgg 120
cacactcaat atggtgtaaa cggagatccc aaaccgccgc acaccatcac gatcgatatg 180
aaaacagtac aaaacgtgaa tggcctttct gtactgccac gtcaggatgg caatcagaat 240
ggatggatcg gacgtcacga ggtgtattta agttctgatg gggtaaattg gggatcgcct 300
gtagcgtctg ggtcctggtt tgccgattcc accacaaagt actctaattt tgagacacgt 360
ccggcccgtt acgtgcgcct tgtcgccatt accgaagcca atgggcaacc gtggacttca 420
attgccgaga ttaacgtatt tcaggcgtct agttacactg ccccgcagcc gggcttgggg 480
cgctggggcc cgacaatcga tcttcccatt gtgccatcgg ccgccgcaat cgagccaacg 540
agcggtcgtg tcttgatgtg gagctcttat cgtcaggatg cgtttgagcg ttctcctggc 600
ggtattacac tgacgagctc atgggaccct agcactggaa tcgtatccga tggcgtaagt 660
accgttaccg ggcacgacat gttttgcccc ggtatctcga tggacgggaa cggtcagatc 720
gtggtcagcg gtggtaatga tgcaaagaaa acttccttat atgattcgag ctcggactct 780
tggattccgg gcccggatat gcaggtcgcg cgtgggtata actcaagtgc gactatgagt 840
gatgggcgcg tatttacgat tggcggcagt tattccggcg gtcaagttga gaagaacggg 900
gaggtttact ccccgagctc gaagacttgg acttcgctgc cgaatgcaaa agttaacccc 960
atgctgaccg ccgataaaca gggtctgtac cgtagcgata atcatgcttg gctgtttggg 1020
tggaaaaagg gtagcgtctt ccaagcaggt ccaagtactg ccatgaactg gtattataca 1080
tctgggtcgg gggacgttaa gagtgcaggg aagcgtcaat cagaccgcgg agtagcccca 1140
gacgccatgt gcggtaatgc cgtaatgtac gacgcagtca aaggcaaaat tttgactttc 1200
gggggctcgc ccgattatca agattcagat gcgactacaa atgcccatat tatcacgctg 1260
ggcgagcctg gcacgagtcc gaatacggta tttgcgagta atgggttact gttcgctcgt 1320
acctttcata cctcggtggt ccttccggac gggagtgtat tcatcacagg aggccagcag 1380
cgcggagttc cactggaaga tagcacaccc gtatttactc cagagatcta cgttcccgaa 1440
caagatactt tttacaaaca aaacccgaat agtatcgttc gtgcgtatca ttccatcagc 1500
ttgttgctgc cggacggacg tgttttcaat ggtggcggtg gcttatgcgg cgattgtgag 1560
acgaaccact ttgatgcgca aatctttacg ccgaattatc tttacgatag caacgggaac 1620
ttagccactc gccctaaaat cacccgtacc tcaacccagt cagtcgtggt cggcgggtgg 1680
atcaccattt ggactgacat gtcgatctcg gccgcaagtt taattcgcta cggaactgct 1740
actcacacgg tgaacaccga tcagcgacgc atcggcttga cgttacaaaa caacggaggt 1800
aattcgtaca gctttcaagt tccgtcggac agcggggttg ctcttccggg atactggatg 1860
ttgttcgtta tgaattccgc tggtgtaccc tccgttgcgt cgacgattaa cgttacccag 1920
ggccaaactg gccaccatca ccatcaccat                                  1950

 
<210> 2860
<211> 650
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of Galactose Oxidase from Fusarium graminearum
 
<400> 2860
Met Ala Ser Ala Pro Ile Gly Val Ala Ile Pro Arg Asn Asn Trp Ala 
1               5                   10                  15      
Val Thr Cys Asp Ser Ala Gln Ser Gly Asn Glu Cys Ile Lys Ala Ile 
            20                  25                  30          
Asp Gly Asn Lys Asp Thr Phe Trp His Thr Gln Tyr Gly Val Asn Gly 
        35                  40                  45              
Asp Pro Lys Pro Pro His Thr Ile Thr Ile Asp Met Lys Thr Val Gln 
    50                  55                  60                  
Asn Val Asn Gly Leu Ser Val Leu Pro Arg Gln Asp Gly Asn Gln Asn 
65                  70                  75                  80  
Gly Trp Ile Gly Arg His Glu Val Tyr Leu Ser Ser Asp Gly Val Asn 
                85                  90                  95      
Trp Gly Ser Pro Val Ala Ser Gly Ser Trp Phe Ala Asp Ser Thr Thr 
            100                 105                 110         
Lys Tyr Ser Asn Phe Glu Thr Arg Pro Ala Arg Tyr Val Arg Leu Val 
        115                 120                 125             
Ala Ile Thr Glu Ala Asn Gly Gln Pro Trp Thr Ser Ile Ala Glu Ile 
    130                 135                 140                 
Asn Val Phe Gln Ala Ser Ser Tyr Thr Ala Pro Gln Pro Gly Leu Gly 
145                 150                 155                 160 
Arg Trp Gly Pro Thr Ile Asp Leu Pro Ile Val Pro Ser Ala Ala Ala 
                165                 170                 175     
Ile Glu Pro Thr Ser Gly Arg Val Leu Met Trp Ser Ser Tyr Arg Gln 
            180                 185                 190         
Asp Ala Phe Glu Arg Ser Pro Gly Gly Ile Thr Leu Thr Ser Ser Trp 
        195                 200                 205             
Asp Pro Ser Thr Gly Ile Val Ser Asp Gly Val Ser Thr Val Thr Gly 
    210                 215                 220                 
His Asp Met Phe Cys Pro Gly Ile Ser Met Asp Gly Asn Gly Gln Ile 
225                 230                 235                 240 
Val Val Ser Gly Gly Asn Asp Ala Lys Lys Thr Ser Leu Tyr Asp Ser 
                245                 250                 255     
Ser Ser Asp Ser Trp Ile Pro Gly Pro Asp Met Gln Val Ala Arg Gly 
            260                 265                 270         
Tyr Asn Ser Ser Ala Thr Met Ser Asp Gly Arg Val Phe Thr Ile Gly 
        275                 280                 285             
Gly Ser Tyr Ser Gly Gly Gln Val Glu Lys Asn Gly Glu Val Tyr Ser 
    290                 295                 300                 
Pro Ser Ser Lys Thr Trp Thr Ser Leu Pro Asn Ala Lys Val Asn Pro 
305                 310                 315                 320 
Met Leu Thr Ala Asp Lys Gln Gly Leu Tyr Arg Ser Asp Asn His Ala 
                325                 330                 335     
Trp Leu Phe Gly Trp Lys Lys Gly Ser Val Phe Gln Ala Gly Pro Ser 
            340                 345                 350         
Thr Ala Met Asn Trp Tyr Tyr Thr Ser Gly Ser Gly Asp Val Lys Ser 
        355                 360                 365             
Ala Gly Lys Arg Gln Ser Asp Arg Gly Val Ala Pro Asp Ala Met Cys 
    370                 375                 380                 
Gly Asn Ala Val Met Tyr Asp Ala Val Lys Gly Lys Ile Leu Thr Phe 
385                 390                 395                 400 
Gly Gly Ser Pro Asp Tyr Gln Asp Ser Asp Ala Thr Thr Asn Ala His 
                405                 410                 415     
Ile Ile Thr Leu Gly Glu Pro Gly Thr Ser Pro Asn Thr Val Phe Ala 
            420                 425                 430         
Ser Asn Gly Leu Leu Phe Ala Arg Thr Phe His Thr Ser Val Val Leu 
        435                 440                 445             
Pro Asp Gly Ser Val Phe Ile Thr Gly Gly Gln Gln Arg Gly Val Pro 
    450                 455                 460                 
Leu Glu Asp Ser Thr Pro Val Phe Thr Pro Glu Ile Tyr Val Pro Glu 
465                 470                 475                 480 
Gln Asp Thr Phe Tyr Lys Gln Asn Pro Asn Ser Ile Val Arg Ala Tyr 
                485                 490                 495     
His Ser Ile Ser Leu Leu Leu Pro Asp Gly Arg Val Phe Asn Gly Gly 
            500                 505                 510         
Gly Gly Leu Cys Gly Asp Cys Glu Thr Asn His Phe Asp Ala Gln Ile 
        515                 520                 525             
Phe Thr Pro Asn Tyr Leu Tyr Asp Ser Asn Gly Asn Leu Ala Thr Arg 
    530                 535                 540                 
Pro Lys Ile Thr Arg Thr Ser Thr Gln Ser Val Val Val Gly Gly Trp 
545                 550                 555                 560 
Ile Thr Ile Trp Thr Asp Met Ser Ile Ser Ala Ala Ser Leu Ile Arg 
                565                 570                 575     
Tyr Gly Thr Ala Thr His Thr Val Asn Thr Asp Gln Arg Arg Ile Gly 
            580                 585                 590         
Leu Thr Leu Gln Asn Asn Gly Gly Asn Ser Tyr Ser Phe Gln Val Pro 
        595                 600                 605             
Ser Asp Ser Gly Val Ala Leu Pro Gly Tyr Trp Met Leu Phe Val Met 
    610                 615                 620                 
Asn Ser Ala Gly Val Pro Ser Val Ala Ser Thr Ile Asn Val Thr Gln 
625                 630                 635                 640 
Gly Gln Thr Gly His His His His His His                         
                645                 650                         

